Bacterial heme sources: the role of heme, hemoprotein receptors and hemophores

The major mechanisms by which Gram-negative bacteria acquire heme from host heme-carrier proteins involve either direct binding to specific outer membrane receptors or release of bacterial hemophores that take up heme from host heme carriers and shuttle it back to specific receptors. The ability to...

Full description

Saved in:
Bibliographic Details
Published in:Current Opinion in Microbiology 2000-04, Vol.3 (2), p.215-220
Main Authors: Wandersman, Cécile, Stojiljkovic, Igor
Format: Article
Language:English
Subjects:
Bacterial Outer Membrane Proteins - chemistry
Bacterial Outer Membrane Proteins - metabolism
Bacterial Proteins - chemistry
Bacterial Proteins - metabolism
Biological Transport
Carrier Proteins - chemistry
Carrier Proteins - metabolism
Gram-Negative Bacteria - chemistry
Gram-Negative Bacteria - metabolism
Heme
Heme - metabolism
heme-carrier proteins
Hemeproteins - chemistry
Hemeproteins - metabolism
Hemoglobin
Hemophore
hemophores
hemoprotein receptors
Iron - metabolism
Membrane Proteins - chemistry
Membrane Proteins - metabolism
Receptor
Siderophore
TonB
Transport
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The major mechanisms by which Gram-negative bacteria acquire heme from host heme-carrier proteins involve either direct binding to specific outer membrane receptors or release of bacterial hemophores that take up heme from host heme carriers and shuttle it back to specific receptors. The ability to interact with and remove heme from carrier proteins distinguishes heme from conceptually similar siderophore and vitamin B12 receptors. Recent genetic, biochemical and crystallization studies have started to unravel the mechanism and molecular interactions between heme-carrier proteins and components of bacterial heme assimilation systems.
ISSN:1369-5274
1879-0364
DOI:10.1016/S1369-5274(00)00078-3