Involvement of capsaicin-sensitive sensory neurons in stress-induced gastroduodenal mucosal injury in rats

The pathogenesis of stress-induced gastroduodenal mucosal injury is complex and incompletely understood. The aim of this investigation was to examine the involvement of gastric and duodenal capsaicin-sensitive neurons in mucosal damage associated with water-restraint stress (WRS) in rats. Following...

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Bibliographic Details
Published in:Digestive diseases and sciences 2000-04, Vol.45 (4), p.830-836
Main Authors: JIAYUAN REN, JIESHENG GAO, OJEAS, H, LIGHTFOOT, S. A, KIDA, M, BREWER, K, HARTY, R. F
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Calcitonin Gene-Related Peptide - metabolism
Capsaicin - metabolism
Duodenum - metabolism
Duodenum - pathology
Gastric Mucosa - metabolism
Gastric Mucosa - pathology
Gastroenterology. Liver. Pancreas. Abdomen
Intestinal Mucosa - metabolism
Intestinal Mucosa - pathology
Male
Medical sciences
Neurons, Afferent - metabolism
Other diseases. Semiology
Rats
Rats, Sprague-Dawley
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Stress, Psychological - complications
Stress, Psychological - metabolism
Stress, Psychological - pathology
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Summary:The pathogenesis of stress-induced gastroduodenal mucosal injury is complex and incompletely understood. The aim of this investigation was to examine the involvement of gastric and duodenal capsaicin-sensitive neurons in mucosal damage associated with water-restraint stress (WRS) in rats. Following WRS, gastroduodenal mucosal injury was quantitated by macroscopic and microscopic methods. Calcitonin gene-related peptide (CGRP) content was measured by radioimmunoassay. WRS-induced mucosal erosive injury in the stomach and duodenum (40.9 +/- 4.2 and 5.1 +/- 0.6 mm2, respectively) was reduced significantly (by 88% and 67%, respectively) by acute intragastric capsaicin administration prior to WRS. In contrast, sensory denervation by chronic capsaicin significantly increased the area of gastric injury and duodenal damage. WRS alone caused a significant reduction (by 52% and -35%, respectively) in gastric and duodenal CGRP content, which was prevented by acute capsaicin treatment. The data suggest that gastric and duodenal sensory neurons and CGRP are involved in the pathogenesis of stress-induced mucosal injury to the stomach and duodenum.
ISSN:0163-2116
1573-2568
DOI:10.1023/A:1005424617101