Congenital anomalies are an independent risk factor for neonatal morbidity and perinatal mortality in preterm birth

• Published in: European journal of obstetrics & gynecology and reproductive biology 2000-05, Vol.90 (1), p.43-49
• Main Authors: Linhart, Yifat, Bashiri, Asher, Maymon, Eli, Shoham-Vardi, Ilana, Furman, Boris, Vardi, Hillel, Mazor, Moshe
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Biological and medical sciences; Case-Control Studies; Congenital Abnormalities - epidemiology; Congenital Abnormalities - mortality; Congenital anomalies; Diseases of mother, fetus and pregnancy; Female; Gestational Age; Gynecology. Andrology. Obstetrics; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases - epidemiology; Infant, Premature, Diseases - mortality; Israel - epidemiology; Maternal Age; Medical sciences; Morbidity; Multivariate Analysis; Neonatal morbidity; Obstetric Labor, Premature; Perinatal mortality; Pregnancy; Pregnancy Complications - epidemiology; Pregnancy. Fetus. Placenta; Preterm birth; Regression Analysis; Risk Factors
• ISSN: 0301-2115; 1872-7654
• DOI: 10.1016/S0301-2115(99)00196-7

Objective: To determine whether congenital anomalies are associated with a high rate of neonatal morbidity in preterm birth. Study design: 312 singletons (22–36 wk) with congenital anomalies that were delivered preterm were compared with a random sample of 936 preterm singleton without congenital anomalies. Data was obtained using the computerized birth discharge records. Statistical analysis included univariate and multivariate logistic regression analyses. Results: Three thousand five hundred and seventy-eight (3578) women with preterm births met the inclusion criteria (singleton with prenatal care). The prevalence of congenital anomalies in the study population was 8.7% (312/3578). Gestational age at delivery was significantly lower in the congenital anomaly group compared with the control (32.0±3.7 SD vs. 34.4±2.7 SD; p