The frequency of mutation in CCR5 gene among Koreans

To better understand a role of the Delta32 allele of the CCR5 gene in HIV-1 transmission and disease progression, we determined the CCR5 genotypes within several groups of Koreans. Amplification of DNA from each subject was achieved with polymerase chain reaction, using the CCR5 specific primer pair...

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Bibliographic Details
Published in:International journal of STD & AIDS 2000-04, Vol.11 (4), p.266-267
Main Authors: OH, M.-D, SUNG SOON KIM, LEE, J.-S, EUN YOUNG KIM, LEE, S, KIM, N, KEUN YONG PARK, KIM, U, KIM, Thoma, KIM, Taigyu, CHOE, K
Format: Article
Language:English
Subjects:
AIDS/HIV
Alleles
Base Sequence
Biological and medical sciences
CCR5 protein
disease progression
DNA, Complementary
Female
Gene Frequency
HIV Infections - genetics
HIV-1
Human immunodeficiency virus
Human viral diseases
Humans
Infectious diseases
Korea
Male
Medical sciences
Molecular Sequence Data
Mutation
Receptors, CCR5 - genetics
Tropical medicine
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:To better understand a role of the Delta32 allele of the CCR5 gene in HIV-1 transmission and disease progression, we determined the CCR5 genotypes within several groups of Koreans. Amplification of DNA from each subject was achieved with polymerase chain reaction, using the CCR5 specific primer pair, which flanks the 32 bp deletion. The 1.2 kb coding sequences of CCR5 were examined to see the possible effects of CCR5 polymorphism. All of the 339 healthy, HIV-uninfected individuals had no mutation in the CCR5 gene. All of the 115 HIV-1-infected patients including 11 long-term non-progressors (LTNPs) and 18 discordant spouses were also wild homozygotes. No variation in the 1.2 kb CCR5 coding sequence was found in 5 LTNPs and 5 discordant spouses. In conclusion, the 32 bp deletion mutant is rarely present in Koreans. Our data suggest that factors other than the CCR5 coding sequences may also play a role in the resistance to HIV infection.
ISSN:0956-4624
1758-1052
DOI:10.1258/0956462001915688