Genetic analysis of a local recurrent tumor after colonic polypectomy

• Published in: Journal of gastroenterology 2001-07, Vol.36 (7), p.500-503
• Main Authors: Takada, M, Fukui, H, Kashiwagi, R, Fujita, M, Kusaka, T, Ono, Y, Kuroda, Y, Kawamata, H, Chiba, T, Fujimori, T
• Format: Article
• Language: English
• Subjects: Adenocarcinoma - genetics; Adenocarcinoma - pathology; Adenocarcinoma - surgery; Aged; Amino Acid Sequence - genetics; Colonic Polyps - genetics; Colonic Polyps - pathology; Colonic Polyps - surgery; Female; Genes, p53 - genetics; Humans; Immunohistochemistry; Neoplasm Recurrence, Local - genetics; Neoplasm Recurrence, Local - pathology; Polymerase Chain Reaction - methods; Polymorphism, Single-Stranded Conformational; Predictive Value of Tests
• ISSN: 0944-1174; 1435-5922
• DOI: 10.1007/s005350170075

After polypectomy, the cut end of the polyp is usually examined by light microscopy to assess the risk of recurrent cancer. Here, we report a recurrent tumor that appeared in the colon 6 years after polypectomy, although cancer cells were not observed in hematoxylin and eosin-stained sections of the cut end of the primary polyp. Retrospectively, the primary polyp and the recurrent tumor were analyzed for mutations of the p53 gene. We detected p53 mutations in the primary polyp, even in the cut end of the polyp. The same set of two p53 mutations was detected in the recurrent tumor. These observations indicate a common origin of the primary tumor and the recurrent tumor. We conclude that it is important to analyze p53 mutations in colonic polyps, especially when the cut end of the polyp is difficult to evaluate histologically, in order to predict recurrence.