Hypertonic-hyperoncotic solutions decrease cardiac troponin I concentrations in peripheral blood in a porcine ischemia-reperfusion model

In this study we addressed the question of whether the measurement of cardiac Troponin I (cTnI) is able to reflect beneficial effects of hypertonic-hyperoncotic solutions after transient cardiac arrest. Ten pigs were anaesthetized and cardiac arrest was induced by electric fibrillation. After 5 minu...

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Bibliographic Details
Published in:Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2001, Vol.53 (2), p.153-156
Main Authors: Bertsch, T., Denz, C., Janke, C., Weiss, M., Fassbender, K., Luiz, T., Ellinger, K., Krieter, H.
Format: Article
Language:English
Subjects:
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthesia: equipment, devices
Animals
Biological and medical sciences
Biomarkers - blood
Disease Models, Animal
Hemodilution
Hemoglobins - analysis
Hydroxyethyl Starch Derivatives - therapeutic use
Hypertonic Solutions - therapeutic use
hypertonic-hyperoncotic solutions
ischemia-reperfusion injury
Medical sciences
microcirculation
Myocardium - metabolism
pigs
Reperfusion Injury - blood
Reperfusion Injury - drug therapy
Swine
Troponin I - blood
Troponin I, cardiac
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Summary:In this study we addressed the question of whether the measurement of cardiac Troponin I (cTnI) is able to reflect beneficial effects of hypertonic-hyperoncotic solutions after transient cardiac arrest. Ten pigs were anaesthetized and cardiac arrest was induced by electric fibrillation. After 5 minutes of global ischemia, cardiac arrest was reversed by electric defibrillation. Upon return of spontaneous circulation 5 animals received hypertonic-hyperoncotic solutions (10% Hydroxyethylstarch 200/0.5 and 7.2% NaCl). The other animals received equivalent volumes of physiological saline. We observed that cTnI serum levels of animals treated with hypertonic-hyperoncotic solutions were significantly lower than those treated with saline. We conclude that hypertonic-hyperoncotic solutions may have cardioprotective effects.
ISSN:0940-2993
1618-1433
DOI:10.1078/0940-2993-00176