Formulation and stability testing of photolabile drugs

Exposure of a drug to irradiation can influence the stability of the formulation, leading to changes in the physicochemical properties of the product. The influence of excipients of frequently used stabilizers is often difficult to predict and, therefore, stability testing of the final preparation i...

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Bibliographic Details
Published in:International Journal of Pharmaceutics 2001-08, Vol.225 (1), p.1-14
Main Author: Tønnesen, Hanne Hjorth
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chemistry, Pharmaceutical
Drug Stability
Excipients - radiation effects
Formulation
General pharmacology
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Photochemistry
Photolabile drugs
Stability testing
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Summary:Exposure of a drug to irradiation can influence the stability of the formulation, leading to changes in the physicochemical properties of the product. The influence of excipients of frequently used stabilizers is often difficult to predict and, therefore, stability testing of the final preparation is important. The selection of a protective packaging must be based on knowledge about the wavelength causing the instability. Details on drug photoreactivity will also be helpful in order to minimize side-effects and/or optimize drug targeting by developing photoresponsive drug delivery systems. This review focuses on practical problems related to formulation and stability testing of photolabile drugs.
ISSN:0378-5173
1873-3476
DOI:10.1016/S0378-5173(01)00746-3