Current techniques of hyperthermic isolated limb perfusion for malignant melanoma

A retrospective study was conducted examining 25 patients with malignant melanoma who were treated by our new protocol for hyperthermic isolated limb perfusion. The characteristics of our techniques include: a lower priming volume of the extracorporeal circuit; a therapeutic temperature range of 40-...

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Bibliographic Details
Published in:Surgery today (Tokyo, Japan) Japan), 2000-01, Vol.30 (4), p.339-342
Main Authors: Tominaga, R, Kohno, H, Mayumi, H, Shiraishi, K, Nagae, S, Nakayama, J, Yasui, H
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic Agents - therapeutic use
Carboplatin - therapeutic use
Chemotherapy, Cancer, Regional Perfusion - methods
Combined Modality Therapy
Extracorporeal Circulation
Extremities
Female
Humans
Hyperthermia, Induced
Interferon-beta - therapeutic use
Lymph Node Excision
Male
Melanoma - therapy
Middle Aged
Retrospective Studies
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Summary:A retrospective study was conducted examining 25 patients with malignant melanoma who were treated by our new protocol for hyperthermic isolated limb perfusion. The characteristics of our techniques include: a lower priming volume of the extracorporeal circuit; a therapeutic temperature range of 40-41 degrees C with 60 min hyperthermic perfusion; a nominal perfusion flow rate of 500 ml/min in the lower limb and 200 ml/min in the upper limb; and combined carboplatin with interferon-beta as the adjuvant chemotherapy drug. In the lower extremity group, the arterial cannula size ranged from 8 to 14 F, while the venous cannula size ranged from 14 to 16 F. In the upper limb group, the arterial cannula size ranged from 6 to 8F and the venous cannula size ranged from 10 to 12F. No patient required any homologous blood transfusion postoperatively. No operative death or major complications occurred during the early postoperative period, confirming the safety of this treatment. Both optimal cannula size selection and maintaining perfusion temperature below 41 degrees C were judged to be important in elimination of vascular and deep tissue injury.
ISSN:0941-1291
1436-2813
DOI:10.1007/s005950050597