The cross-sectional association between blood pressure and Alzheimer's disease in a biracial community population of older persons

The relation of blood pressure to Alzheimer's disease (AD) is complex because both an association of high blood pressure with increased risk of the disease and lower blood pressure as a consequence of the disease are possible. We examined the cross-sectional association of blood pressure and AD...

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Bibliographic Details
Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2000-03, Vol.55 (3), p.M130-M136
Main Authors: Morris, M C, Scherr, P A, Hebert, L E, Bennett, D A, Wilson, R S, Glynn, R J, Evans, D A
Format: Article
Language:English
Subjects:
African Continental Ancestry Group
Aged
Aged, 80 and over
Aging
Alzheimer Disease - ethnology
Alzheimer Disease - physiopathology
Alzheimer's disease
Blood Pressure
Cross-Sectional Studies
Dementia, Vascular - ethnology
Dementia, Vascular - physiopathology
European Continental Ancestry Group
Female
Humans
Male
Older people
Prevalence
Risk Factors
Stroke - ethnology
Stroke - physiopathology
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Summary:The relation of blood pressure to Alzheimer's disease (AD) is complex because both an association of high blood pressure with increased risk of the disease and lower blood pressure as a consequence of the disease are possible. We examined the cross-sectional association of blood pressure and AD in the Chicago Health and Aging Project (CHAP), a study of a geographically defined, biracial community. After in-home interviews with 6.162 residents > or =65 years, a stratified random sample of 729 participants was clinically evaluated; 709 had blood pressures measured, and 243 were diagnosed with AD. In logistic regression models adjusted for age, sex, education, and race there was no association between blood pressure measured as a continuous variable and Alzheimer's disease. In categorical analyses, however, prevalence of Alzheimer's disease was significantly higher among persons with low systolic pressure (
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/55.3.m130