Cerebral perfusion and arterial transit time changes during task activation determined with continuous arterial spin labeling

Perfusion imaging by arterial spin labeling (ASL) can be highly sensitive to the transit time from the labeling site to the tissue. We report the results of a study designed to separate the transit time and perfusion contributions to activation in ASL images accompanying motor and visual stimulation...

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Bibliographic Details
Published in:Magnetic resonance in medicine 2000-05, Vol.43 (5), p.739-746
Main Authors: Gonzalez-At, Julio B., Alsop, David C., Detre, John A.
Format: Article
Language:English
Subjects:
activation
arterial transit time
Biological and medical sciences
Blood Flow Velocity
cerebral blood flow
Cerebrovascular Circulation - physiology
Humans
Image Enhancement
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging - methods
Medical sciences
motor cortex
Nervous system
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Spin Labels
visual cortex
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Summary:Perfusion imaging by arterial spin labeling (ASL) can be highly sensitive to the transit time from the labeling site to the tissue. We report the results of a study designed to separate the transit time and perfusion contributions to activation in ASL images accompanying motor and visual stimulation. Fractional transit time decreases were found to be comparable to fractional perfusion increases and the transit time change was found to be the greatest contributor to ASL signal change in ASL sequences without delayed acquisition. The implications for activation imaging with ASL and the arterial control of flow are discussed. Magn Reson Med 43:739–746, 2000. © 2000 Wiley‐Liss, Inc.
ISSN:0740-3194
1522-2594
DOI:10.1002/(SICI)1522-2594(200005)43:5<739::AID-MRM17>3.0.CO;2-2