Molecular Basis for the Relationship Between Thrombosis and Cancer

Cancer patients are highly susceptible to thromboembolic complications, which some have estimated accounts for a significant percentage of the morbidity and mortality of the disease. Not all of the mechanisms for the production of the hypercoagulable state characteristic of cancer are entirely under...

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Bibliographic Details
Published in:Thrombosis research 2001-06, Vol.102 (6), p.V215-V224
Main Authors: Rickles, Frederick R, Falanga, Anna
Format: Article
Language:English
Subjects:
Angiogenesis
Biological and medical sciences
Blood and lymphatic vessels
Cancer
Cardiology. Vascular system
Cell Communication
Cytokines
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Fibrinolysis
Hemostasis - drug effects
Humans
Medical sciences
Neoplasm Proteins - adverse effects
Neoplasm Proteins - metabolism
Neoplasms - complications
Neoplasms - metabolism
Neoplasms - pathology
Procoagulants
Thromboembolism
Thrombosis - etiology
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Summary:Cancer patients are highly susceptible to thromboembolic complications, which some have estimated accounts for a significant percentage of the morbidity and mortality of the disease. Not all of the mechanisms for the production of the hypercoagulable state characteristic of cancer are entirely understood. Those that are known seem to interdigitate the biology of cancer with the major regulatory pathways that mediate blood coagulation, platelet–vessel wall interaction, fibrinolysis and inflammatory cytokine production. In other words, the events responsible for thrombosis in cancer appears to be a result of an over exuberant host response in an attempt to delimit tumor growth. In this brief review, therefore, we attempt to put into the context of tumor growth, angiogenesis and metastasis the current information about the pathogenesis of venous thromboembolism (VTE).
ISSN:0049-3848
1879-2472
DOI:10.1016/S0049-3848(01)00285-7