Cross-Reactivity of Antibodies to Type 6B and 6A Polysaccharides of Streptococcus pneumoniae Evoked by Pneumococcal Conjugate Vaccines, in Infants

Streptococcus pneumoniae serotypes 6B and 6A are important causes of infections, yet only 6B is included in current vaccines. It is, therefore, crucial to evaluate whether functional antibodies are produced against both types after vaccination. Concentration and opsonophagocytic activity (OPA) of an...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 2001-09, Vol.184 (6), p.789-793
Main Authors: Väkeväinen, Merja, Eklund, Carita, Eskola, Juhani, Käyhty, Helena
Format: Article
Language:English
Subjects:
Antibodies
Antibodies, Bacterial - blood
Antibody Formation
Antigens, Bacterial - immunology
Bacteriology
Biological and medical sciences
Children
Concise Communications
Conjugate vaccines
Cross reaction
Cross Reactions
Fundamental and applied biological sciences. Psychology
Human viral diseases
Humans
Immune response
Immunoglobulin G - blood
Infant
Infants
Infections
Infectious diseases
Medical sciences
Microbiology
Phagocytosis
Pneumococcal Vaccines - immunology
Polysaccharides
Polysaccharides, Bacterial - immunology
Regression Analysis
Serotyping
Streptococcus pneumoniae
Streptococcus pneumoniae - classification
Streptococcus pneumoniae - immunology
Vaccination
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Vaccines, Conjugate - immunology
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Streptococcus pneumoniae serotypes 6B and 6A are important causes of infections, yet only 6B is included in current vaccines. It is, therefore, crucial to evaluate whether functional antibodies are produced against both types after vaccination. Concentration and opsonophagocytic activity (OPA) of antibodies to 6B and 6A polysaccharides were determined in serum samples from infants immunized with 3 different pneumococcal conjugate vaccines containing serotype 6B. In all vaccine groups, a significant correlation was found between the anti-6B and -6A antibody concentration and OPA. However, OPA to the vaccine serotype was detectable more commonly than OPA to the cross-reactive type. Furthermore, 5%–15% of the serum samples showed high OPA against the 6B but not the 6A strain. On average, 2–6 times more anti-6B antibodies were needed for 50% opsonophagocytic killing of the type 6A than the type 6B strain. Although pneumococcal type 6B conjugate vaccines elicit antibodies that cross-react with type 6A, not all anti-6B antibodies are functionally cross-reactive
ISSN:0022-1899
1537-6613
DOI:10.1086/322984