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Verbalactone, a New Macrocyclic Dimer Lactone from the Roots of Verbascum undulatum with Antibacterial Activity

A novel macrocyclic dimer lactone, named verbalactone, was isolated from the roots of Verbascum undulatum and exhibited interesting antibacterial activity. It is the first time that 1,7-dioxacyclododecane is reported as the ring system of a natural product. The structure and the absolute stereochemi...

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Published in:	Journal of natural products (Washington, D.C.) D.C.), 2001-08, Vol.64 (8), p.1093-1094
Main Authors:	MAGIATIS, Prokopios, SPANAKIS, Dimitris, MITAKU, Sofia, TSITSA, Eugenia, MENTIS, Andreas, HARVALA, Catherine
Format:	Article
Language:	English
Subjects:	1,7-Dioxacyclododecane Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Biological and medical sciences Chromatography, Thin Layer Decanoic Acids - chemistry Decanoic Acids - pharmacology Enterobacter aerogenes - drug effects Escherichia coli - drug effects General pharmacology Greece Klebsiella pneumoniae - drug effects Lactobacillus casei - drug effects Lactones - chemistry Lactones - isolation & purification Lactones - pharmacology Magnetic Resonance Spectroscopy Mass Spectrometry Medical sciences Microbial Sensitivity Tests Molecular Conformation Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Roots - chemistry Plants, Medicinal - chemistry Pseudomonas aeruginosa - drug effects Salmonella enteritidis - drug effects Spectrophotometry, Infrared Staphylococcus aureus - drug effects Staphylococcus epidermidis - drug effects Stereoisomerism verbalactone Verbascum undulatum
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container_end_page	1094
container_issue	8
container_start_page	1093
container_title	Journal of natural products (Washington, D.C.)
container_volume	64
creator	MAGIATIS, Prokopios SPANAKIS, Dimitris MITAKU, Sofia TSITSA, Eugenia MENTIS, Andreas HARVALA, Catherine
description	A novel macrocyclic dimer lactone, named verbalactone, was isolated from the roots of Verbascum undulatum and exhibited interesting antibacterial activity. It is the first time that 1,7-dioxacyclododecane is reported as the ring system of a natural product. The structure and the absolute stereochemistry of the new compound were determined by spectral methods and chemical correlation.
doi_str_mv	10.1021/np010025r
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Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Roots - chemistry ; Plants, Medicinal - chemistry ; Pseudomonas aeruginosa - drug effects ; Salmonella enteritidis - drug effects ; Spectrophotometry, Infrared ; Staphylococcus aureus - drug effects ; Staphylococcus epidermidis - drug effects ; Stereoisomerism ; verbalactone ; Verbascum undulatum</subject><ispartof>Journal of natural products (Washington, D.C.), 2001-08, Vol.64 (8), p.1093-1094</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1125671$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11520236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MAGIATIS, Prokopios</creatorcontrib><creatorcontrib>SPANAKIS, Dimitris</creatorcontrib><creatorcontrib>MITAKU, Sofia</creatorcontrib><creatorcontrib>TSITSA, Eugenia</creatorcontrib><creatorcontrib>MENTIS, Andreas</creatorcontrib><creatorcontrib>HARVALA, Catherine</creatorcontrib><title>Verbalactone, a New Macrocyclic Dimer Lactone from the Roots of Verbascum undulatum with Antibacterial Activity</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>A novel macrocyclic dimer lactone, named verbalactone, was isolated from the roots of Verbascum undulatum and exhibited interesting antibacterial activity. It is the first time that 1,7-dioxacyclododecane is reported as the ring system of a natural product. 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source	American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects	1,7-Dioxacyclododecane Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Biological and medical sciences Chromatography, Thin Layer Decanoic Acids - chemistry Decanoic Acids - pharmacology Enterobacter aerogenes - drug effects Escherichia coli - drug effects General pharmacology Greece Klebsiella pneumoniae - drug effects Lactobacillus casei - drug effects Lactones - chemistry Lactones - isolation & purification Lactones - pharmacology Magnetic Resonance Spectroscopy Mass Spectrometry Medical sciences Microbial Sensitivity Tests Molecular Conformation Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Roots - chemistry Plants, Medicinal - chemistry Pseudomonas aeruginosa - drug effects Salmonella enteritidis - drug effects Spectrophotometry, Infrared Staphylococcus aureus - drug effects Staphylococcus epidermidis - drug effects Stereoisomerism verbalactone Verbascum undulatum
title	Verbalactone, a New Macrocyclic Dimer Lactone from the Roots of Verbascum undulatum with Antibacterial Activity
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