Elevation of blood NAD level after moderate exercise in young women and mice

We previously reported that the blood NAD levels are decreased by severe exercise, and administration of nicotinamide, a precursor of NAD, improves the endurance capacity of mice. In the present study, we determined whether moderate exercise changes the blood NAD levels in humans and mice. College f...

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Bibliographic Details
Published in:Journal of Nutritional Science and Vitaminology 2001, Vol.47(2), pp.177-179
Main Authors: Fukuwatari, T. (Shiga Prefectural Univ., Hikone (Japan)), Shibata, K, Ishihara, K, Fushiki, T, Sugimoto, E
Format: Article
Language:English
Subjects:
Adult
Animals
Biological and medical sciences
BLOOD
exercise
Exercise - physiology
Female
Fundamental and applied biological sciences. Psychology
Humans
Male
Metabolisms and neurohumoral controls
MICE
Mice, Inbred ICR
NAD
NAD - blood
NAD - pharmacokinetics
NADP
NADP - blood
NICOTINAMIDE
Nitrogen metabolism. Proteins. Glycoproteins. Nucleic acids. Collagen
PHYSICAL ACTIVITY
Physical Exertion - physiology
tryptophan
Tryptophan - blood
Vertebrates: anatomy and physiology, studies on body, several organs or systems
WOMEN
YOUTH
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Summary:We previously reported that the blood NAD levels are decreased by severe exercise, and administration of nicotinamide, a precursor of NAD, improves the endurance capacity of mice. In the present study, we determined whether moderate exercise changes the blood NAD levels in humans and mice. College female students exercised moderately with bike-ergometers. The blood NAD levels elevated after moderate exercise. Mice were forced to swim in a running water pool for 5 min as a moderate exercise, 15 min as a strong exercise, and until exhaustion as a severe exercise (average swimming time was 28.7 min). A 5 min swim gave a result similar to that of moderate exercise by human subjects. However, the blood NAD levels decreased after all-out exercise. The changes in whole blood tryptophan (a precursor of pyridine nucleotides) levels were similar to that in NAD. The glucose levels in whole blood and the non-esterified fatty acid levels in serum decreased according to exercising time. These data are the first demonstration of moderate exercise raising the blood NAD levels in human and mice. Elevation of the blood NAD levels may reflect changes in niacin metabolism that occur in response to exercise.
ISSN:0301-4800
1881-7742
DOI:10.3177/jnsv.47.177