Hemodynamic effects of positive end-expiratory pressure during partial liquid ventilation in newborn lambs

Background/Purpose: The aim of this study was to compare the effect of positive end-expiratory pressure (PEEP) application on hemodynamics, lung mechanics, and oxygenation in the intact newborn lung during conventional ventilation (CV) and partial liquid ventilation (PLV) at functional residual capa...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pediatric surgery 2001-09, Vol.36 (9), p.1327-1332
Main Authors: Overfield, D.Michael, Bennett, Stephen H., Goetzman, Boyd W., Milstein, Jay M., Moon-Grady, Anita J.
Format: Article
Language:English
Subjects:
Airway Resistance
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Animals, Newborn
Biological and medical sciences
Emergency and intensive respiratory care
Female
gas exchange
hemodynamics
Hemodynamics - physiology
Intensive care medicine
Liquid Ventilation - methods
lung compliance
Male
Medical sciences
Models, Animal
newborn lambs
normal lung
oxygenation
partial liquid ventilation
Perfluorocarbon
positive end-expiratory pressure
Positive-Pressure Respiration - methods
Pulmonary Gas Exchange
Reference Values
Respiratory Physiological Phenomena
Sensitivity and Specificity
Sheep
Tidal Volume
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background/Purpose: The aim of this study was to compare the effect of positive end-expiratory pressure (PEEP) application on hemodynamics, lung mechanics, and oxygenation in the intact newborn lung during conventional ventilation (CV) and partial liquid ventilation (PLV) at functional residual capacity (FRC). CV or PLV modes of ventilation do not affect hemodynamics nor the optimum PEEP for oxygenation. Methods: Seven newborn lambs (1 to 3 days old) were instrumented to measure pulmonary hemodynamics and airway mechanics. Each lamb was used as their own control to compare different modes of ventilation (CV followed by PLV) under graded variations of PEEP (4, 8, 12, and 16 cm H2O) on the influence on pulmonary blood flow and pulmonary vascular resistance. Results: There was a significant drop in pulmonary blood flow (PBF) from baseline (PEEP of 4 cm H2O on CV, 1,229 ± 377 mL/min) in both modes of ventilation on a PEEP of 16 cm H2O (CV, 750 ± 318 mL/min v PLV, 926 ± 396 mL/min, respectively; P
ISSN:0022-3468
1531-5037
DOI:10.1053/jpsu.2001.26360