Placebo-Controlled Trial of Sertraline in the Treatment of Binge Eating Disorder

OBJECTIVE: The authors' goal was to assess the efficacy of sertraline in the treatment of binge eating disorder.METHOD: Thirty-four outpatients with DSM-IV binge eating disorder were randomly assigned to receive either sertraline (N=18) or placebo (N=16) in a 6-week, double-blind, flexible-dose...

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Bibliographic Details
Published in:The American journal of psychiatry 2000-06, Vol.157 (6), p.1004-1006
Main Authors: McElroy, Susan L., Casuto, Leah S., Nelson, Eric B., Lake, Kathleen A., Soutullo, Cesar A., Keck, Paul E., Hudson, James I.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Ambulatory Care
Binge eating
Body Mass Index
Clinical trials
Double-Blind Method
Drug therapy
Eating disorders
Efficacy
Feeding and Eating Disorders - diagnosis
Feeding and Eating Disorders - drug therapy
Feeding and Eating Disorders - psychology
Female
Humans
Middle Aged
Placebos
Psychiatric Status Rating Scales - statistics & numerical data
Serotonin Uptake Inhibitors - therapeutic use
Sertraline
Sertraline - therapeutic use
Severity of Illness Index
Treatment
Treatment Outcome
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Summary:OBJECTIVE: The authors' goal was to assess the efficacy of sertraline in the treatment of binge eating disorder.METHOD: Thirty-four outpatients with DSM-IV binge eating disorder were randomly assigned to receive either sertraline (N=18) or placebo (N=16) in a 6-week, double-blind, flexible-dose (50-200 mg) study. Except for response level, outcome measures were analyzed by random regression methods, with treatment-by-time interaction as the effect measure.RESULTS: Compared with placebo, sertraline was associated with a significantly greater rate of reduction in the frequency of binges, clinical global severity, and body mass index as well as a significantly greater rate of increase in clinical global improvement. Patients receiving sertraline who completed the study demonstrated a higher level of response, although the effect was not significant.CONCLUSIONS: In a 6-week trial, sertraline was effective and well tolerated in the treatment of binge eating disorder.
ISSN:0002-953X
1535-7228
DOI:10.1176/appi.ajp.157.6.1004