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Placebo-Controlled Trial of Sertraline in the Treatment of Binge Eating Disorder
OBJECTIVE: The authors' goal was to assess the efficacy of sertraline in the treatment of binge eating disorder.METHOD: Thirty-four outpatients with DSM-IV binge eating disorder were randomly assigned to receive either sertraline (N=18) or placebo (N=16) in a 6-week, double-blind, flexible-dose...
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| Published in: | The American journal of psychiatry 2000-06, Vol.157 (6), p.1004-1006 |
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| container_end_page | 1006 |
| container_issue | 6 |
| container_start_page | 1004 |
| container_title | The American journal of psychiatry |
| container_volume | 157 |
| creator | McElroy, Susan L. Casuto, Leah S. Nelson, Eric B. Lake, Kathleen A. Soutullo, Cesar A. Keck, Paul E. Hudson, James I. |
| description | OBJECTIVE: The authors' goal was to assess the efficacy of sertraline in the treatment of binge eating disorder.METHOD: Thirty-four outpatients with DSM-IV binge eating disorder were randomly assigned to receive either sertraline (N=18) or placebo (N=16) in a 6-week, double-blind, flexible-dose (50-200 mg) study. Except for response level, outcome measures were analyzed by random regression methods, with treatment-by-time interaction as the effect measure.RESULTS: Compared with placebo, sertraline was associated with a significantly greater rate of reduction in the frequency of binges, clinical global severity, and body mass index as well as a significantly greater rate of increase in clinical global improvement. Patients receiving sertraline who completed the study demonstrated a higher level of response, although the effect was not significant.CONCLUSIONS: In a 6-week trial, sertraline was effective and well tolerated in the treatment of binge eating disorder. |
| doi_str_mv | 10.1176/appi.ajp.157.6.1004 |
| format | article |
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Except for response level, outcome measures were analyzed by random regression methods, with treatment-by-time interaction as the effect measure.RESULTS: Compared with placebo, sertraline was associated with a significantly greater rate of reduction in the frequency of binges, clinical global severity, and body mass index as well as a significantly greater rate of increase in clinical global improvement. Patients receiving sertraline who completed the study demonstrated a higher level of response, although the effect was not significant.CONCLUSIONS: In a 6-week trial, sertraline was effective and well tolerated in the treatment of binge eating disorder.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/appi.ajp.157.6.1004</identifier><identifier>PMID: 10831483</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>United States: American Psychiatric Publishing</publisher><subject>Adolescent ; Adult ; Ambulatory Care ; Binge eating ; Body Mass Index ; Clinical trials ; Double-Blind Method ; Drug therapy ; Eating disorders ; Efficacy ; Feeding and Eating Disorders - diagnosis ; Feeding and Eating Disorders - drug therapy ; Feeding and Eating Disorders - psychology ; Female ; Humans ; Middle Aged ; Placebos ; Psychiatric Status Rating Scales - statistics & numerical data ; Serotonin Uptake Inhibitors - therapeutic use ; Sertraline ; Sertraline - therapeutic use ; Severity of Illness Index ; Treatment ; Treatment Outcome</subject><ispartof>The American journal of psychiatry, 2000-06, Vol.157 (6), p.1004-1006</ispartof><rights>Copyright American Psychiatric Association Jun 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a428t-c68ffa892e0bc1f1e735ca9000b893bdb7ee15162bfa7aab095b28b7d228d6e73</citedby><cites>FETCH-LOGICAL-a428t-c68ffa892e0bc1f1e735ca9000b893bdb7ee15162bfa7aab095b28b7d228d6e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/appi.ajp.157.6.1004$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/appi.ajp.157.6.1004$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,780,784,2855,21626,21627,21628,27924,27925,31000,77794,77799</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10831483$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McElroy, Susan L.</creatorcontrib><creatorcontrib>Casuto, Leah S.</creatorcontrib><creatorcontrib>Nelson, Eric B.</creatorcontrib><creatorcontrib>Lake, Kathleen A.</creatorcontrib><creatorcontrib>Soutullo, Cesar A.</creatorcontrib><creatorcontrib>Keck, Paul E.</creatorcontrib><creatorcontrib>Hudson, James I.</creatorcontrib><title>Placebo-Controlled Trial of Sertraline in the Treatment of Binge Eating Disorder</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>OBJECTIVE: The authors' goal was to assess the efficacy of sertraline in the treatment of binge eating disorder.METHOD: Thirty-four outpatients with DSM-IV binge eating disorder were randomly assigned to receive either sertraline (N=18) or placebo (N=16) in a 6-week, double-blind, flexible-dose (50-200 mg) study. Except for response level, outcome measures were analyzed by random regression methods, with treatment-by-time interaction as the effect measure.RESULTS: Compared with placebo, sertraline was associated with a significantly greater rate of reduction in the frequency of binges, clinical global severity, and body mass index as well as a significantly greater rate of increase in clinical global improvement. Patients receiving sertraline who completed the study demonstrated a higher level of response, although the effect was not significant.CONCLUSIONS: In a 6-week trial, sertraline was effective and well tolerated in the treatment of binge eating disorder.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Ambulatory Care</subject><subject>Binge eating</subject><subject>Body Mass Index</subject><subject>Clinical trials</subject><subject>Double-Blind Method</subject><subject>Drug therapy</subject><subject>Eating disorders</subject><subject>Efficacy</subject><subject>Feeding and Eating Disorders - diagnosis</subject><subject>Feeding and Eating Disorders - drug therapy</subject><subject>Feeding and Eating Disorders - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Placebos</subject><subject>Psychiatric Status Rating Scales - statistics & numerical data</subject><subject>Serotonin Uptake Inhibitors - therapeutic use</subject><subject>Sertraline</subject><subject>Sertraline - 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Except for response level, outcome measures were analyzed by random regression methods, with treatment-by-time interaction as the effect measure.RESULTS: Compared with placebo, sertraline was associated with a significantly greater rate of reduction in the frequency of binges, clinical global severity, and body mass index as well as a significantly greater rate of increase in clinical global improvement. Patients receiving sertraline who completed the study demonstrated a higher level of response, although the effect was not significant.CONCLUSIONS: In a 6-week trial, sertraline was effective and well tolerated in the treatment of binge eating disorder.</abstract><cop>United States</cop><pub>American Psychiatric Publishing</pub><pmid>10831483</pmid><doi>10.1176/appi.ajp.157.6.1004</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0002-953X |
| ispartof | The American journal of psychiatry, 2000-06, Vol.157 (6), p.1004-1006 |
| issn | 0002-953X 1535-7228 |
| language | eng |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); American Psychiatric Publishing Journals |
| subjects | Adolescent Adult Ambulatory Care Binge eating Body Mass Index Clinical trials Double-Blind Method Drug therapy Eating disorders Efficacy Feeding and Eating Disorders - diagnosis Feeding and Eating Disorders - drug therapy Feeding and Eating Disorders - psychology Female Humans Middle Aged Placebos Psychiatric Status Rating Scales - statistics & numerical data Serotonin Uptake Inhibitors - therapeutic use Sertraline Sertraline - therapeutic use Severity of Illness Index Treatment Treatment Outcome |
| title | Placebo-Controlled Trial of Sertraline in the Treatment of Binge Eating Disorder |
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