Tissue and Wound Healing Effects of Short Duration Postoperative Oxygen Therapy

The purpose of this study was to determine the effects of 28% oxygen given in the first 36 hours after surgery on tissue oxygen, collagen deposition, and clinical healing outcomes. Twenty-four subjects having cervical spine surgical procedures participated in a randomized, repeated-measures pilot st...

Full description

Saved in:
Bibliographic Details
Published in:Biological research for nursing 2001-01, Vol.2 (3), p.206-215
Main Authors: Whitney, JoAnne D., Heiner, Stacy, Mygrant, Brenda I., Wood, Connie
Format: Article
Language:English
Subjects:
Adult
Aged
Female
Humans
Hydroxyproline - metabolism
Male
Manometry - methods
Middle Aged
Nursing
Oxygen - metabolism
Oxygen Inhalation Therapy
Pilot Projects
Postoperative Care
Statistics, Nonparametric
Surgical Wound Infection - prevention & control
Wound Healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The purpose of this study was to determine the effects of 28% oxygen given in the first 36 hours after surgery on tissue oxygen, collagen deposition, and clinical healing outcomes. Twenty-four subjects having cervical spine surgical procedures participated in a randomized, repeated-measures pilot study of tissue and healing effects of postoperative supplemental oxygen. The treatment group (n = 13) received 28% oxygen for the first 36 postoperative hours, whereas the control group (n = 11) was maintained on room air. Subcutaneous tissue oxygen and temperature were measured at intervals up to 36 hours postsurgery. Wound healing was evaluated by hydroxyproline content in a subcutaneous polytetrafluoroethylene tube removed on the 7th postoperative day. Clinical outcomes were evaluated for the 30 days post–hospital discharge. Subjects in the treatment group had significantly higher tissue oxygen tension overall, and at postoperative hours 1, 2, 18, and 36, with mean values 10 to 20 mm Hg higher than control subjects. Significant differences were not found in hydroxyproline levels or clinical wound outcome measures. Low level, short duration, supplemental oxygen increased and sustained wound tissue oxygen and was well tolerated by subjects. Larger studies of populations at risk for wound complications are needed to investigate variables of dose and duration of oxygen therapy in relation to clinical and cellular wound healing outcomes.
ISSN:1099-8004
1552-4175
DOI:10.1177/109980040100200306