Antinociceptive effect of the essential oil from Cymbopogon citratus in mice

The essential oil (EO) from leaves of Cymbopogon citratus increased the reaction time to thermal stimuli both after oral (25 mg/kg) and intraperitoneal (25–100 mg/kg) administration. EO (50–200 mg/kg, p.o. or i.p.) strongly inhibited the acetic acid-induced writhings in mice. In the formalin test, E...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2000-06, Vol.70 (3), p.323-327
Main Authors: Viana, G.S.B, Vale, T.G, Pinho, R.S.N, Matos, F.J.A
Format: Article
Language:English
Subjects:
Acetates
Analgesics - antagonists & inhibitors
Analgesics - isolation & purification
Analgesics - pharmacology
Animals
Antinociceptive activity
Behavior, Animal - drug effects
Caribbean Region
Chromatography, Gas
Cymbopogon citratus
Essential oil
Formaldehyde
human health and safety
Male
Mass Spectrometry
medicine
Mice
Naloxone - pharmacology
Narcotic Antagonists - pharmacology
nonfood plant products
Oils, Volatile - isolation & purification
Oils, Volatile - pharmacology
Pain Measurement - drug effects
Plant Leaves - chemistry
Plants, Medicinal - chemistry
Poaceae - chemistry
Reaction Time - drug effects
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Summary:The essential oil (EO) from leaves of Cymbopogon citratus increased the reaction time to thermal stimuli both after oral (25 mg/kg) and intraperitoneal (25–100 mg/kg) administration. EO (50–200 mg/kg, p.o. or i.p.) strongly inhibited the acetic acid-induced writhings in mice. In the formalin test, EO (50 and 200 mg/kg, i.p.) inhibited preferentially the second phase of the response, causing inhibitions of 100 and 48% at 200 mg/kg, i.p. and 100 mg/kg, p.o., respectively. On the other hand, the opioid antagonist naloxone blocked the central antinociceptive effect of EO, suggesting that EO acts both at peripheral and central levels.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(99)00168-3