Influence of sources of dietary oils on the life span of stroke-prone spontaneously hypertensive rats

• Published in: Lipids 2000-04, Vol.35 (4), p.409-420
• Main Authors: Ratnayake, W.M.N, Plouffe, L, Hollywood, R, L'Abbe, M.R, Hidiroglou, N, Sarwar, G, Mueller, R
• Format: Article
• Language: English
• Subjects: Animals; Biochemical analysis; Blood pressure; Body weight; Brain Chemistry; Canola oil; chemical composition; cholesterol; Cholesterol - administration & dosage; Cholesterol - analogs & derivatives; Cholesterol - analysis; Diet; dietary fat; Dietary Fats, Unsaturated - administration & dosage; Dietary Fats, Unsaturated - analysis; Dietary Fats, Unsaturated - pharmacology; Drinking water; Edible oils; Fatty acids; Fatty Acids - analysis; Fatty Acids, Monounsaturated - administration & dosage; Fatty Acids, Monounsaturated - pharmacology; Hypertension; Hypertension - mortality; Life span; Liver - chemistry; longevity; mortality; Oils & fats; phytosterols; Phytosterols - administration & dosage; Phytosterols - analysis; Phytosterols - pharmacology; Rapeseed Oil; Rats; Rats, Inbred SHR; Rodents; Safflower oil; Sitosterols - administration & dosage; Sitosterols - analysis; Sodium chloride; Soybean oil; Soybeans; Stroke - mortality; Sulfur; Survival; Survival Rate; Thiobarbituric Acid Reactive Substances - analysis; Vegetable oils; Vegetables; Vitamin E - administration & dosage; Vitamin E - analysis
• ISSN: 0024-4201; 1558-9307
• DOI: 10.1007/s11745-000-539-5

In recent studies, the life span of stroke‐prone spontaneously hypertensive (SHRSP) rats was altered by a variety of dietary fats. It was relatively shorter in rats fed canola oil as the sole source of fat. The present study was performed to find out whether the fatty acid profile and the high content of sulfur compounds in canola oil could modulate the life span of SHRSP rats. SHRSP rats (47 d old, n=23/group) were matched by body weight and systolic blood pressure and fed semipurified diets containing 10% canola oil, high‐palmitic canola oil, low‐sulfur canola oil, soybean oil, high‐oleic safflower oil, a fat blend that mimicked the fatty acid composition of canola oil, or a fat blend high in saturated fatty acids. A 1% sodium chloride solution was used as drinking water to induce hypertension. After consuming the diets for 37 d, five rats from each dietary group were killed for collection of blood and tissue samples for biochemical analysis. The 18 remaining animals from each group were used for determining their life span. The mean survival time of SHRSP rats fed canola oil (87.4±4.0 d) was not significantly different (P>0.05) from those fed low‐sulfur canola oil (89.7±8.5 d), suggesting that content of sulfur in canola oil has no effect on the life span of SHRSP rats. The SHRSP rats fed the noncanola oil‐based diets lived longer (mean survival time difference was 6–13 d, P