A comparison of the lung deposition of budesonide from Easyhaler®, Turbuhaler®and pMDI plus spacer in asthmatic patients

Inhaled corticosteroids in pressurized metered does inhalers (pMDIs) are often delivered via a large volume spacer device, but these are bulky and inconvenient. Dry powder inhalers (DPIs) provide a highly portable and convenient propellant-free alternative to pMDIs for asthma maintenance therapy. Ho...

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Bibliographic Details
Published in:Respiratory medicine 2001-09, Vol.95 (9), p.720-727
Main Authors: HIRST, P.H, BACON, R.E, PITCAIRN, G.R, SILVASTI, M, NEWMAN, S.P
Format: Article
Language:English
Subjects:
Administration, Inhalation
Adolescent
Adult
Anti-Asthmatic Agents - administration & dosage
Asthma - diagnostic imaging
Asthma - drug therapy
Biological and medical sciences
Budesonide - administration & dosage
budesonide, lung deposition
Cross-Over Studies
Easyhaler
Equipment Design
Female
Forced Expiratory Volume - drug effects
Humans
Male
Medical sciences
Middle Aged
Nebulizers and Vaporizers - standards
Peak Expiratory Flow Rate - drug effects
Pharmacology. Drug treatments
pMDI
Powders
Radionuclide Imaging
Respiratory system
spacer
Statistics, Nonparametric
Technetium
Treatment Outcome
Turbuhaler
Vital Capacity - drug effects
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Summary:Inhaled corticosteroids in pressurized metered does inhalers (pMDIs) are often delivered via a large volume spacer device, but these are bulky and inconvenient. Dry powder inhalers (DPIs) provide a highly portable and convenient propellant-free alternative to pMDIs for asthma maintenance therapy. However, each DPI could have unique in vivo delivery characteristics. In order to quantify the total and regional lung deposition of budesonide (200 μ g) from (a) Easyhaler®, (b) Turbuhaler®and (c) pMDI plus Nebuhaler®750 ml spacer, a three-way randomized cross-over study was carried out in 12 mild to moderate asthmatic patients. Deposition was quantified by the imaging technique of gamma scintigraphy. Optimal inhalation techniques were used throughout. Mean (SD) whole lung deposition (% metered dose) was similar for Easyhaler®[18·5 (7·8) %] and Turbuhaler®[21·8 (8·2) %], but was significantly higher for pMDI plus Nebuhaler®[44·1 (10·0) %, P
ISSN:0954-6111
1532-3064
DOI:10.1053/rmed.2001.1107