Microsatellite Markers and Genetic Mapping in Plasmodium falciparum

Whole-genome methods are changing the scope of biological questions that can be addressed in malaria research. In the rich context provided by Plasmodium falciparum genome sequencing, genetic mapping is a powerful tool for identifying genes involved in parasite development, invasion, transmission an...

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Bibliographic Details
Published in:Parasitology today (Regular ed.) 2000-07, Vol.16 (7), p.307-312
Main Authors: Ferdig, M.T, Su, X-z
Format: Article
Language:English
Subjects:
Allelic association
Animals
Biological and medical sciences
Chromosome Mapping
Fundamental and applied biological sciences. Psychology
Genetic Linkage
Genetic Variation - genetics
Genetics of eukaryotes. Biological and molecular evolution
Haplotype
Humans
Linkage disequilibrium
Malaria, Falciparum - parasitology
Microsatellite markers
Microsatellite Repeats - genetics
Plasmodium falciparum
Plasmodium falciparum - classification
Plasmodium falciparum - genetics
Polymorphism
Population genetics, reproduction patterns
Protozoa
Quantitive trait loci
Simple sequence repeats
Trait mapping
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Summary:Whole-genome methods are changing the scope of biological questions that can be addressed in malaria research. In the rich context provided by Plasmodium falciparum genome sequencing, genetic mapping is a powerful tool for identifying genes involved in parasite development, invasion, transmission and drug resistance. The recent development of a high-resolution P. falciparum linkage map consisting of hundreds of microsatellite markers will facilitate an integrated genomic approach to understanding the relationship between genetic variations and biological phenotypes. Here, Michael Ferdig and Xin-zhuan Su provide an overview for applying microsatellite markers and genetic maps to gene mapping, parasite typing and studies of parasite population changes.
ISSN:0169-4758
1873-1473
DOI:10.1016/S0169-4758(00)01676-8