Risk of heparin lock‐related bleeding when using indwelling venous catheter in haemodialysis

• Published in: Nephrology, dialysis, transplantation dialysis, transplantation, 2001-10, Vol.16 (10), p.2072-2074
• Main Authors: Karaaslan, Hüseyin, Peyronnet, Pierre, Benevent, Daniel, Lagarde, Christian, Rince, Michel, Leroux‐Robert, Claude
• Format: Article
• Language: English
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Catheters, Indwelling - adverse effects; Emergency and intensive care: renal failure. Dialysis management; Hemorrhage - etiology; Heparin - administration & dosage; Heparin - adverse effects; heparin locking; Humans; indwelling venous haemodialysis catheters; Intensive care medicine; Medical sciences; Partial Thromboplastin Time; Renal Dialysis - adverse effects; Risk Factors; Time Factors
• ISSN: 0931-0509; 1460-2385
• DOI: 10.1093/ndt/16.10.2072

Background. The indwelling venous catheter such as Dual‐Cath® or Twin‐Cath® is widely used in haemodialysis. Although the manufacturer recommends filling the catheter lumen with heparin after the dialysis session to prevent clotting, little is known about the systemic effects of such a procedure. Methods. Twenty haemodialysis patients with Dual‐Cath® were studied. Dialysis anticoagulation was achieved by injecting a bolus of dalteparin. The patient/control ratio of activated partial thromboplastin time (aPTT) was determined at the end of the session immediately before and 10 min after locking with 2 ml of undiluted heparin (10 000 U/catheter). We also determined the catheter volume for each patient and measured aPTT immediately before and 10 min after heparin locking with this patient‐specific volume. Catheter patency was followed over a 2‐week period. Results. The aPTT values determined at the end of two consecutive dialysis sessions were nearly normal, respectively 1.29 (±0.17) and 1.33 (±0.22), whereas all patients had uncoagulable blood (aPTT >3.75) 10 min after locking with 2 ml of heparin. When catheter volumes were individually calculated, they were found to be substantially lower than 2.0 ml (1.21±0.12 for the arterial branch and 1.27±0.13 for the venous branch). aPTT was only 2.42±0.73 10 min after locking with the estimated volumes except in one patient (aPTT >3.75). No catheter clotting was observed despite these smaller locking volumes. Conclusions. A risk of inducing serious bleeding does indeed exist with Dual‐Cath® heparin locking, especially in postoperative patients. This risk can be reduced by measuring catheter length at the time of placement in order to ensure an appropriate lock volume. Sodium citrate, polygeline, or urokinase are possible alternatives to heparin.