Highly Satisfactory Procedures for the Pd-Catalyzed Cross Coupling of Aryl Electrophiles with in Situ Generated Alkynylzinc Derivatives

Two new and very efficient procedures (Procedures A and B) are reported for the Pd-catalyzed cross coupling of aryl electrophiles with terminal alkynes via their in situ conversion into alkynylzinc derivatives. Procedure A is particularly valuable in cases where electron-deficient alkynes are used,...

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Bibliographic Details
Published in:Organic letters 2001-10, Vol.3 (20), p.3111-3113
Main Authors: Anastasia, Luigi, Negishi, Ei-ichi
Format: Article
Language:English
Subjects:
Alkynes - chemical synthesis
Alkynes - chemistry
Iodobenzenes - chemistry
Organometallic Compounds - chemistry
Palladium - chemistry
Zinc - chemistry
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Summary:Two new and very efficient procedures (Procedures A and B) are reported for the Pd-catalyzed cross coupling of aryl electrophiles with terminal alkynes via their in situ conversion into alkynylzinc derivatives. Procedure A is particularly valuable in cases where electron-deficient alkynes are used, while Procedure B is operationally simple and very satisfactory in less demanding cases.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol010145q