Tracking of oocyte dysmorphisms for ICSI patients may prove relevant to the outcome in subsequent patient cycles

BACKGROUND: We determined whether oocyte dysmorphisms, especially repetition of specific dysmorphisms from cycle to cycle, had a prognostic impact on intracytoplasmic sperm injection (ICSI) outcome. METHODS: ICSI patients (n = 67) were grouped as follows: group 1 >50% phenotypically dysmorphic oo...

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Published in:Human reproduction (Oxford) 2001-10, Vol.16 (10), p.2118-2123
Main Authors: Meriano, James S., Alexis, Jennifer, Visram-Zaver, Shirin, Cruz, Micheal, Casper, Robert F.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cohort Studies
cytoplasm
Embryo Implantation
Female
Fundamental and applied biological sciences. Psychology
Humans
ICSI outcome
implantation rates
Mammalian female genital system
Morphology. Physiology
Oocytes - ultrastructure
oocytes dysmorphisms
organelle clustering
Organelles - ultrastructure
Pregnancy
Pregnancy Rate
Prognosis
Retrospective Studies
Sperm Injections, Intracytoplasmic
Treatment Outcome
Vertebrates: reproduction
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Summary:BACKGROUND: We determined whether oocyte dysmorphisms, especially repetition of specific dysmorphisms from cycle to cycle, had a prognostic impact on intracytoplasmic sperm injection (ICSI) outcome. METHODS: ICSI patients (n = 67) were grouped as follows: group 1 >50% phenotypically dysmorphic oocytes per cohort (cytoplasmic and extra-cytoplasmic dysmorphisms) with no repetition of a specific dysmorphism from cycle one to cycle two (36 cycles and 274 oocytes); group 2 >50% dysmorphic oocytes per cohort and repetition of the same dysmorphism from cycle one to cycle two (32 cycles and 313 oocytes); group 3 (control)
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/16.10.2118