Reduced cerebral glucose metabolism in subjects with incidental hyperintensities on magnetic resonance imaging

Objective: To clarify the significance of incidental and asymptomatic hyperintensities on T 2-weighted magnetic resonance images (MRI) in adults, we examined the relationship between a variety of these lesions and cerebral metabolism evaluated by positron emission tomography (PET) with 18F-labeled f...

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Bibliographic Details
Published in:Journal of the neurological sciences 2000-05, Vol.176 (1), p.21-27
Main Authors: Takahashi, Wakoh, Takagi, Shigeharu, Ide, Michiru, Shohtsu, Akira, Shinohara, Yukito
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Asymptomatic CVD
Biological and medical sciences
Blood Glucose - metabolism
Brain - diagnostic imaging
Brain - metabolism
Brain - pathology
Brain Diseases - diagnostic imaging
Brain Diseases - metabolism
Brain Diseases - pathology
Cerebral Cortex - diagnostic imaging
Cerebral Cortex - metabolism
Cerebral Cortex - pathology
Cerebral glucose metabolism
Cognitive function
Female
Fluorodeoxyglucose F18 - metabolism
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Multivariate Analysis
Nervous system (semeiology, syndromes)
Nervous system as a whole
Neurology
Neuropsychological Tests
Periventricular hyperintensities
Positron emission tomography
Tomography, Emission-Computed
White matter hyperintensities on MRI
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Summary:Objective: To clarify the significance of incidental and asymptomatic hyperintensities on T 2-weighted magnetic resonance images (MRI) in adults, we examined the relationship between a variety of these lesions and cerebral metabolism evaluated by positron emission tomography (PET) with 18F-labeled fluorodeoxyglucose ([ 18F]FDG). Subjects and methods: Two hundred and thirty-one persons with hyperintensities on T 2-weighted MRI but without overt neurological disease (mean age 60±9 years) were studied. MR hyperintensities were classified into deep and/or subcortical white matter hyperintensities (DSWMHs), periventricular hyperintensities (PVHs) and hyperintensities in the basal ganglia and/or thalamus (HBGTs). The relationship between these lesions and cerebral metabolic rate of glucose (CMRgl) measured by [ 18F]FDG-PET was investigated. Results: The CMRgl values in white matter and cerebral cortex in the group with severe PVHs were lower than those in the group with mild PVHs ( P
ISSN:0022-510X
1878-5883
DOI:10.1016/S0022-510X(00)00286-0