Second gas effect of N2O on oxygen uptake

The concept of the second gas effect is well known, however, there have been no studies that showed the relationship between alveolar oxygen concentration and arterial oxygen tension (PaO2) after the inhalation of nitrous oxide (N2O) in humans. The purpose of this study was to examine the changes in...

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Bibliographic Details
Published in:Canadian journal of anesthesia 2000-06, Vol.47 (6), p.506-510
Main Authors: NISHIKAWA, K.-I, KUNIMOTO, F, ISA, Y, MIYOSHI, S, TAKAHASHI, K.-I, MORITA, T, ARII, H, GOTO, F
Format: Article
Language:English
Subjects:
Adult
Anesthetics, Inhalation - pharmacology
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Bone surgery
Female
Humans
Male
Medical sciences
Middle Aged
Neuropharmacology
Nitrous Oxide - pharmacology
Oxygen
Oxygen Consumption - drug effects
Pharmacology. Drug treatments
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Summary:The concept of the second gas effect is well known, however, there have been no studies that showed the relationship between alveolar oxygen concentration and arterial oxygen tension (PaO2) after the inhalation of nitrous oxide (N2O) in humans. The purpose of this study was to examine the changes in both end-tidal oxygen fraction (F(ET)O2) and PaO2 after N2O inhalation in patients under general anesthesia. Fifteen patients scheduled for elective orthopedic surgery were enrolled in this study. Anesthesia was maintained with the continuous infusion of propofol and with nitrogen (N2) and oxygen (O2) (6 L x min(-1), F1O2, 0.33). In all patients, the lungs were ventilated with a Servo 900C ventilator equipped with a gas mixer for O2, N2O, and N2. After obtaining baseline data, N2 was replaced with N2O maintaining FIO2 constant at 0.33. The changes in fractional concentration of O2, N2O, and N2 were continuously measured using mass spectrometer in a breath-by-breath basis. PaO2 and hemodynamic data were obtained at 1, 5, 10, 30 and 60 min after the start of N2O inhalation. Five minutes after N2O inhalation, F(ET)O2 increased from 0.27+/-0.01 to 0.31+/-0.02 (P
ISSN:0832-610X
1496-8975
DOI:10.1007/BF03018940