Characterization of gammadelta T cells expressing CD158b, a killer cell inhibitory receptor, in a patient with chronic CD4(+) lymphocytopenia and disseminated Mycobacterium intracellulare infection

A population of Vdelta1(+)Vgamma9(-) gammadelta T cells that represented almost the totality (84%) of circulating lymphocytes in a patient with chronic, non-HIV-related, CD4 lymphocytopenia complicated by a disseminated Mycobacterium intracellulare infection was characterized. These gammadelta(+) T...

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Bibliographic Details
Published in:Clinical immunology (Orlando, Fla.) Fla.), 2000-07, Vol.96 (1), p.67-75
Main Authors: Airò, P, Caruso, A, Stellini, R, Antonioli, C, Malacarne, F, Licenziati, S, Albertini, A, Cattaneo, R, Imberti, L
Format: Article
Language:English
Subjects:
AIDS/HIV
Antigens, CD - classification
Apoptosis - immunology
CD28 Antigens - immunology
CD8 Antigens - immunology
Cell Adhesion
Cell Division
Chronic Disease
Cytotoxicity, Immunologic - immunology
Endothelium, Vascular - cytology
Female
Humans
Immunophenotyping
Killer Cells, Natural - immunology
Macrophage-1 Antigen - immunology
Middle Aged
Mycobacterium avium Complex - immunology
Mycobacterium avium-intracellulare Infection - blood
Mycobacterium avium-intracellulare Infection - complications
Mycobacterium avium-intracellulare Infection - immunology
Receptors, Antigen, T-Cell, gamma-delta - immunology
Receptors, Immunologic - biosynthesis
Receptors, Immunologic - immunology
Receptors, KIR
Receptors, KIR2DL3
T-Lymphocytopenia, Idiopathic CD4-Positive - blood
T-Lymphocytopenia, Idiopathic CD4-Positive - complications
T-Lymphocytopenia, Idiopathic CD4-Positive - immunology
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Summary:A population of Vdelta1(+)Vgamma9(-) gammadelta T cells that represented almost the totality (84%) of circulating lymphocytes in a patient with chronic, non-HIV-related, CD4 lymphocytopenia complicated by a disseminated Mycobacterium intracellulare infection was characterized. These gammadelta(+) T cells expressed a single killer inhibitory receptor (CD158b) and their phenotype (CD8(+)CD57(+)CD27(-)CD28(-)) indicated that, although CD45RA(+), they were not naive. However, the absence of large granular lymphocyte morphology, the impaired proliferative activity, the high susceptibility to apoptosis, and the total lack of cytotoxic ability suggested that these gammadelta cells were in a resting state. A high percentage of the cells did not harbor the CD11b integrin alpha chain and exhibited a decreased capability to bind endothelial cells. This defect might represent the mechanism whereby they remained trapped in the circulation.
ISSN:1521-6616