Radical Cyclization of β-Aminoacrylates:  Synthesis of (−)-Indolizidine 223AB

(−)-Indolizidine 223AB was synthesized via radical cyclization of the β-aminoacrylate derivative of a trans-2,5-disubstituted pyrrolidine. The trans-2,5-disubstituted pyrrolidine substrate was prepared by radical cyclization of a Ses-protected β-aminoacrylate.

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Bibliographic Details
Published in:Organic letters 2000-07, Vol.2 (14), p.2169-2171
Main Authors: Lee, Eun, Jeong, Min, Sun Joon, Hong, Sukwon, Lim, Jaehong, Kim, Sang Kyun, Kim, Hak Joong, Choi, Bum Gyu, Koo, Ki Chul
Format: Article
Language:English
Subjects:
Animals
Anura - metabolism
Cyclization
Indicators and Reagents
Indoles - chemical synthesis
Indolizines
Skin - chemistry
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Description
Summary:(−)-Indolizidine 223AB was synthesized via radical cyclization of the β-aminoacrylate derivative of a trans-2,5-disubstituted pyrrolidine. The trans-2,5-disubstituted pyrrolidine substrate was prepared by radical cyclization of a Ses-protected β-aminoacrylate.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol006094z