Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content

Departments of 1  Medicine and 2  Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261; and 3  School of Physical and Health Education, Queen's University, Kingston, Ontario, Canada K7L 3N6 The purpose of this investigation was to validate that in vivo measurement of skeletal mus...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 2000-07, Vol.89 (1), p.104-110
Main Authors: Goodpaster, Bret H, Kelley, David E, Thaete, F. Leland, He, Jing, Ross, Robert
Format: Article
Language:English
Subjects:
Adult
Anatomy & physiology
Biological and medical sciences
Body Composition
Diabetes
Diabetes Mellitus, Type 2 - diagnostic imaging
Female
Humans
Male
Medical sciences
Metabolic diseases
Middle Aged
Muscular system
Obesity
Obesity - diagnostic imaging
Phantoms, Imaging
Psoas Muscles - chemistry
Psoas Muscles - diagnostic imaging
Reproducibility of Results
Tomography, X-Ray Computed - standards
Triglycerides - analysis
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Summary:Departments of 1  Medicine and 2  Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261; and 3  School of Physical and Health Education, Queen's University, Kingston, Ontario, Canada K7L 3N6 The purpose of this investigation was to validate that in vivo measurement of skeletal muscle attenuation (MA) with computed tomography (CT) is associated with muscle lipid content. Single-slice CT scans performed on phantoms of varying lipid concentrations revealed good concordance between attenuation and lipid concentration ( r 2  = 0.995); increasing the phantom's lipid concentration by 1 g/100 ml decreased its attenuation by ~1 Hounsfield unit (HU). The test-retest coefficient of variation for two CT scans performed in six volunteers was 0.51% for the midthigh and 0.85% for the midcalf, indicating that the methodological variability is low. Lean subjects had significantly higher ( P  
ISSN:8750-7587
1522-1601
DOI:10.1152/jappl.2000.89.1.104