Comparison of serum specific IgE antibodies to staphylococcal enterotoxins between atopic children with and without atopic dermatitis

Background: The skin of patients with atopic dermatitis (AD) exhibits a striking susceptibility to colonization and infection by Staphylococcus aureus. The exotoxins secreted by S. aureus can act as superantigens and classic allergens, inducing the production of functionally relevant specific IgE an...

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Bibliographic Details
Published in:Allergy (Copenhagen) 2000-07, Vol.55 (7), p.641-646
Main Authors: Lin, Y. T., Yang, Y. H., Hwang, Y. W., Tsai, M. J., Tsao, P. N., Chiang, B. L., Shau, W. Y., Wang, L. F.
Format: Article
Language:English
Subjects:
Adolescent
Allergic diseases
Antibodies, Bacterial - blood
atopic dermatitis
Biological and medical sciences
Child
Child, Preschool
Dermatitis, Atopic - blood
Dermatitis, Atopic - immunology
Enterotoxins - immunology
Female
Humans
Immunoglobulin E - blood
Immunopathology
Infant
Male
Medical sciences
Severity of Illness Index
Skin allergic diseases. Stinging insect allergies
specific IgE
staphylococcal enterotoxin
Staphylococcal Skin Infections - blood
Staphylococcal Skin Infections - immunology
Staphylococcus aureus
Staphylococcus aureus - immunology
superantigen
Tropical medicine
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Summary:Background: The skin of patients with atopic dermatitis (AD) exhibits a striking susceptibility to colonization and infection by Staphylococcus aureus. The exotoxins secreted by S. aureus can act as superantigens and classic allergens, inducing the production of functionally relevant specific IgE antibodies. The aim of this study was to compare the levels and positive rates of serum staphylococcal enterotoxin A (SEA)‐ and staphylococcal enterotoxin B (SEB)‐specific IgE between atopic children with and without AD. Methods: Sixty children with AD, 55 children with respiratory allergy without AD, and 24 nonatopic healthy children were studied. The levels and positive rates of serum SEA‐ and SEB‐specific IgE were compared among three groups. The correlation between the levels or positive rates of serum SEA/SEB‐specific IgE and the severity of AD or the presence of previous skin infections was studied. Results: The children with AD had significantly higher levels and positive rates of serum SEA‐ and SEB‐specific IgE than the atopic children without AD (P
ISSN:0105-4538
1398-9995
DOI:10.1034/j.1398-9995.2000.00523.x