Local excision for rectal cancer

• Published in: Journal of surgical oncology 2000-06, Vol.74 (2), p.158-162
• Main Authors: Balani, Alessandro, Turoldo, Angelo, Braini, Andrea, Scaramucci, Monica, Roseano, Mauro, Leggeri, Aldo
• Format: Article
• Language: English
• Subjects: Abdomen - surgery; Adenocarcinoma - mortality; Adenocarcinoma - pathology; Adenocarcinoma - surgery; Adult; Aged; Aged, 80 and over; Anastomosis, Surgical - methods; Biological and medical sciences; Endoscopy; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; local excision; Male; Medical sciences; Middle Aged; Neoplasm Recurrence, Local - epidemiology; Perineum - surgery; rectal cancer; Rectal Neoplasms - mortality; Rectal Neoplasms - pathology; Rectal Neoplasms - surgery; Rectum - surgery; Retrospective Studies; Stomach, duodenum, intestine, rectum, anus; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Survival Analysis; T1-T2 tumours; Tumors; Urologic Surgical Procedures - methods
• ISSN: 0022-4790; 1096-9098
• DOI: 10.1002/1096-9098(200006)74:2<158::AID-JSO15>3.0.CO;2-E

Background and Objectives The aim of this retrospective study is to evaluate the results of local excision (LE) for rectal cancer for curative purposes. Methods From 1969 to December 1997, a total of 456 operations were performed for surgical treatment of rectal carcinoma (262 males and 194 females, mean age 66 years). Twenty patients (4.1%) underwent LE (7 males and 13 females, median age 65 years). Patients were selected for LE if they met the following criteria during preoperative staging: tumors staged as T1‐T2,N0,M0, grading G1 or G2, and accessible location. Types of LE performed were: 13 transanal excisions (Francillon's technique), 2 Mason surgeries, 2 endoscopic excisions, and 3 transanal endoscopic microsurgeries. Results There was no in‐hospital mortality among LE patients. Thirteen tumors were T1 and 7 were T2; all 20 were adenocarcinoma, 14 G1 and 6 G2. There was no specific morbidity, and aspecific morbidity was minimal (5%). There were no local recurrences, but 2 patients (10%) had secondary lesions. Five‐year overall survival following LE was 87.4%. Comparing T1 and T2 tumors treated with abdominoperineal resection (APR) and SSR (17 T1 and 42 T2, all adenocarcinoma), in‐hospital mortality and specific morbidity were respectively 1.7% (P = 0.55) and 28% (P = 0.007). There were 5 (8.5%) local recurrences (P = 0.17) and 6 (10.2%) metastatic lesions. Five‐year overall survival was similar to LE (88.3%; P = 0.76). Conclusions LE for rectal carcinoma might only be successfully performed in selected patients with correct preoperative staging. In the LE cases reported five‐year overall survival, local recurrence, and in‐hospital mortality were similar to APR and SSR, while there was a statistically significant difference following LE in terms of specific morbidity. J. Surg. Oncol. 2000;74:158–162. © 2000 Wiley‐Liss, Inc.