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Synthesis and biological activities of an α-methyl and a β-methyl carbapenem and the corresponding unsubstituted compound
The carbapenem potassium salts 4, 7 and 8 were prepared. Their rates of β-lactam hydrolysis and their biological activities, particularly their β-lactamase inhibiting properties, were examined and explained on the basis of their different substitution and pyramidality.
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| Published in: | Bioorganic & medicinal chemistry letters 2000-06, Vol.10 (12), p.1389-1391 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c390t-b9ee0d5aa04bcf209cbea436897695fa3c82cc9ed6a99e0e7c2abb6c0d98a2793 |
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| cites | cdi_FETCH-LOGICAL-c390t-b9ee0d5aa04bcf209cbea436897695fa3c82cc9ed6a99e0e7c2abb6c0d98a2793 |
| container_end_page | 1391 |
| container_issue | 12 |
| container_start_page | 1389 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 10 |
| creator | Pfaendler, Hans Rudolf Weishaupt, Ralf Meffert, Helmut |
| description | The carbapenem potassium salts
4,
7 and
8 were prepared. Their rates of β-lactam hydrolysis and their biological activities, particularly their β-lactamase inhibiting properties, were examined and explained on the basis of their different substitution and pyramidality. |
| doi_str_mv | 10.1016/S0960-894X(00)00248-1 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2000-06, Vol.10 (12), p.1389-1391 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71271398 |
| source | Elsevier |
| subjects | Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Carbapenems - chemical synthesis Carbapenems - chemistry Carbapenems - pharmacology Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments |
| title | Synthesis and biological activities of an α-methyl and a β-methyl carbapenem and the corresponding unsubstituted compound |
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