Insect peptide hormones: a selective review of their physiology and potential application for pest control

Our knowledge on primary structure, synthesis, release, receptor binding, structure–activity relationships, mode of action and degradation of, mainly, neuropeptides from insects has increased dramatically during the last 10 years or so. Here, five case studies are presented, which deal selectively w...

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Bibliographic Details
Published in:Pest management science 2003-10, Vol.59 (10), p.1063-1075
Main Authors: Gäde, Gerd, Goldsworthy, Graham J
Format: Article
Language:English
Subjects:
agonists
Amino Acid Sequence
Animals
antagonists
Behavior, Animal - drug effects
Biological and medical sciences
case studies
Control
Culicidae
energy metabolism
feeding behavior
Freshwater
Fundamental and applied biological sciences. Psychology
growth and development
immune system
Insect Control - methods
Insect Hormones - genetics
Insect Hormones - metabolism
Insect Hormones - pharmacology
insect neuropeptides
insect pests
Insecta
Insecta - genetics
Insecta - metabolism
kinins
locomotion
mechanism of action
Molecular Sequence Data
muscles
Neuropeptides - genetics
Neuropeptides - metabolism
Neuropeptides - pharmacology
peptide hormones
pest control
pheromone biosynthesis activating neuropeptide
Phytopathology. Animal pests. Plant and forest protection
Protozoa. Invertebrates
pseudopeptide analogues
reproduction
Reproduction - drug effects
safe insecticides
snowdrop lectin fusion protein
structure-activity relationships
trypsin
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Summary:Our knowledge on primary structure, synthesis, release, receptor binding, structure–activity relationships, mode of action and degradation of, mainly, neuropeptides from insects has increased dramatically during the last 10 years or so. Here, five case studies are presented, which deal selectively with effects on: reproduction (trypsin modulating oostatic factor in mosquito); energy metabolism, locomotion and the immune system (adipokinetic hormones); water and ion balance, and feeding behaviour (diuretic hormones, kinins, sulfakinins); sex attraction (pheromone biosynthesis activating neuropeptide); and growth and development, and muscle activity (allatostatins). The literature is reviewed in the context of how the knowledge on neuropeptides has been and can be used for the design of novel, safe and selective compounds to control pest insects in the foreseeable future.
ISSN:1526-498X
1526-4998
DOI:10.1002/ps.755