Expression of caveolin-1 is associated with poor prognosis of patients with squamous cell carcinoma of the lung

Background: Caveolin-1, as a major component of caveolae, is involved in the regulation of cell cycle by impacting various signaling pathways. Previous studies of caveolin-1 in cancer showed two contrary results. In most in vitro studies, caveolin-1 played a role as a tumor suppressor. On the other...

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Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2003-11, Vol.42 (2), p.195-202
Main Authors: Yoo, Seong-Ho, Park, Young Sik, Kim, Hyeong-Ryul, Sung, Sook Whan, Kim, Joo Hyun, Shim, Young Soo, Lee, Soong Deok, Choi, Yoon-La, Kim, Min-Kyung, Chung, Doo Hyun
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Squamous Cell - pathology
Caveolin 1
Caveolins - biosynthesis
Disease Progression
Female
Humans
Immunohistochemistry
Lung
Lung Neoplasms - pathology
Male
Medical sciences
Middle Aged
Neoplasm Staging
Pathologic stage
Pneumology
Prognosis
Retrospective Studies
Sensitivity and Specificity
Squamous cell carcinoma
Survival Analysis
Tumors of the respiratory system and mediastinum
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Summary:Background: Caveolin-1, as a major component of caveolae, is involved in the regulation of cell cycle by impacting various signaling pathways. Previous studies of caveolin-1 in cancer showed two contrary results. In most in vitro studies, caveolin-1 played a role as a tumor suppressor. On the other hand, the elevated expression of caveolin-1 was often reported to be associated with poor clinical outcome in human studies. These results indicate differential biological functions of caveolin-1 depending on the development and progression stage of cancer in vivo. Methods: To clarify the correlation between the clinicopathologic profiles of pulmonary squamous cell carcinomas and the expression of caveolin-1, 107 cases of formalin-fixed and paraffin-embedded tissues of pulmonary squamous cell carcinomas were immunohistochemically evaluated for the expression of caveolin-1 by the tissue-array method. Results: Caveolin-1 was expressed in 34 cases (31.7%) among 107 cases of pulmonary squamous cell carcinoma. The expression of caveolin-1 was statistically correlated with pathologic stage (stage I and II vs. III; P
ISSN:0169-5002
1872-8332
DOI:10.1016/S0169-5002(03)00287-3