Evaluation of adherence to the regulations for declaration of notification of transfusion reactions with fever and chills. A study of the Association Inter-Régionale du Sud-Est d'Hémovigilance (AIRSEH)

Febrile non-hemolytic transfusion reactions (FNHTR) are the most frequently reported acute adverse effects of blood products, and should be notified within 48 h according to the hemovigilance regulation. In order to study the conformity of these notifications and to search for factors associated wit...

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Published in:Transfusion clinique et biologique : journal de la Société française de transfusion sanguine 2003-10, Vol.10 (5), p.324-330
Main Authors: Renaudier, P, Brunie, J, Vial, J, Campergue, L, Augey, L, Arnuti, B, Gay, V, Garin, L, Pleyber, M, Guinard, S, Benetaieb, B, Adeleine, P, Sasco, A J
Format: Article
Language:fre
Subjects:
Adult
Aged
Blood Banks - organization & administration
Blood Banks - statistics & numerical data
Chills - epidemiology
Chills - etiology
Disease Notification - legislation & jurisprudence
Female
Fever - epidemiology
Fever - etiology
France - epidemiology
Guideline Adherence - statistics & numerical data
Humans
Male
Middle Aged
Retrospective Studies
Transfusion Reaction
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Summary:Febrile non-hemolytic transfusion reactions (FNHTR) are the most frequently reported acute adverse effects of blood products, and should be notified within 48 h according to the hemovigilance regulation. In order to study the conformity of these notifications and to search for factors associated with non-conformity, we retrospectively studied all FNHTR notified by voluntary centers of the AIRSEH group from 1st September 1994 to 31st December 1999. Seven hundred and sixty-one FNHTR were registered by 10 centers, most of them were benign (grade 1); 67.8% were non-conform. The non-conformity was associated with the number of biological investigations performed (median number, respectively, 4.24 and 2.94--P = 0.038--in non-conform and conform notifications--P = 0.038) in univariate analysis. Using a logistic regression model, center and severity were the only two factors significantly associated with non-conformity. Different center practices, and in particular the interface between the hospital and the blood bank, may be responsible for the effect center. Moreover, the non-conformity concerns first of all benign FNHTR. A stronger separation between alert and epidemiological surveillance is proposed in order to improve the notifications' conformity.
ISSN:1246-7820