The essential role of calcium in induction of the DSCR1 (ADAPT78) gene

In the last few years we have discovered several new oxidant stress-inducible genes, all of which provide partial protection against acute oxidative stress. These include: Adapt15, Adapt33, Adapt66, Adapt73, Adapt78, and Adapt116. All of these genes contain a calcium response element, all can be ind...

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Bibliographic Details
Published in:BioFactors (Oxford) 2001, Vol.15 (2-4), p.91-93
Main Authors: Davies, Kelvin J. A., Harris, Cathryn D., Ermak, Gennady
Format: Article
Language:English
Subjects:
Calcium - physiology
Gene Expression Regulation - physiology
Humans
Intracellular Signaling Peptides and Proteins
Muscle Proteins - genetics
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Summary:In the last few years we have discovered several new oxidant stress-inducible genes, all of which provide partial protection against acute oxidative stress. These include: Adapt15, Adapt33, Adapt66, Adapt73, Adapt78, and Adapt116. All of these genes contain a calcium response element, all can be induced by calcium ionophores such as A23187 in the presence of calcium; and by other agents, such as thapsigargin and cyclopiazonic acid, that increase intracellular calcium concentrations. In contrast, cell-permeant calcium chelators, such as BAPTA-AM, can completely block the induction of all the 'adapt' genes. Of all the adapt genes, Adapt78 is the most responsive to calcium signaling. We propose that by responding to stress-induced calcium fluxes the DSCR1 (Adapt78) protein can help protect cells against stress-induced apoptosis. In contrast, chronic overexpression of the DSCR1 (Adapt78) protein in the brain may result in hyperphosphorylation of the tau protein, leading to the formation of neurofibrillary tangles which are strongly associated with Alzheimers disease.
ISSN:0951-6433
1872-8081
DOI:10.1002/biof.5520150208