New Silica-Immobilized Chiral Amino Alcohol for the Enantioselective Addition of Diethylzinc to Benzaldehyde

A readily available chiral amino alcohol has been immobilized on silica by sol−gel synthesis and grafting. The solid prepared according to the latter method led to the best enantioselectivity (77% ee) described for the asymmetric addition of diethylzinc to benzaldehyde using inorganic solids.

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Bibliographic Details
Published in:Organic letters 2003-11, Vol.5 (23), p.4333-4335
Main Authors: Fraile, José M, Mayoral, José A, Serrano, Jorge, Pericàs, Miquel A, Solà, Lluís, Castellnou, David
Format: Article
Language:English
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Description
Summary:A readily available chiral amino alcohol has been immobilized on silica by sol−gel synthesis and grafting. The solid prepared according to the latter method led to the best enantioselectivity (77% ee) described for the asymmetric addition of diethylzinc to benzaldehyde using inorganic solids.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0355985