A Ruthenium Nitrosyl That Rapidly Delivers NO to Proteins in Aqueous Solution upon Short Exposure to UV Light

Two Ru(III) complexes, [Ru(PaPy3)(Cl)](BF4) (2) and [Ru(PaPy3)(NO)](BF4)2 (3) (PaPy3H = N,N‘-bis(2-pyridylmethyl)amine-N-ethyl-2-pyridine-2-carboxamide), have been synthesized and characterized by spectroscopy and X-ray diffraction. Nitrosyl complex 3 has been prepared by passage of purified NO gas...

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Bibliographic Details
Published in:Inorganic chemistry 2003-11, Vol.42 (23), p.7363-7365
Main Authors: Patra, Apurba K, Mascharak, Pradip K
Format: Article
Language:English
Subjects:
Animals
Horses
Molecular Structure
Myocardium - chemistry
Myoglobin - chemistry
Nitric Oxide - chemistry
Organometallic Compounds - chemistry
Organometallic Compounds - radiation effects
Ruthenium - chemistry
Ruthenium - radiation effects
Ultraviolet Rays
Water - chemistry
X-Ray Diffraction
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Summary:Two Ru(III) complexes, [Ru(PaPy3)(Cl)](BF4) (2) and [Ru(PaPy3)(NO)](BF4)2 (3) (PaPy3H = N,N‘-bis(2-pyridylmethyl)amine-N-ethyl-2-pyridine-2-carboxamide), have been synthesized and characterized by spectroscopy and X-ray diffraction. Nitrosyl complex 3 has been prepared by passage of purified NO gas to the hot methanolic solution of the chloro derivative 2. Complex 3 exhibits νΝΟ stretching frequency at 1899 cm-1 indicating a {Ru−NO}6 configuration. Clean 1H NMR spectra of 3 in D2O and CD3CN confirm the S = 0 ground state. When an aqueous solution of [Ru(PaPy3)(NO)](BF4)2 is exposed to low intensity UV light, it rapidly loses NO and forms [Ru(PaPy3)(H2O)]2+. This reaction can be conveniently used to transfer NO to proteins such as myoglobin (Mb) and cytochrome c oxidase. The NO transfer reaction is clean and occurs upon short exposure to light.
ISSN:0020-1669
1520-510X
DOI:10.1021/ic030110h