Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial

Mild alterations in temperature have prominent effects on ischemic cell injury and stroke outcome. Elevated core body temperature (CBT), even if mild, may exacerbate neuronal injury and worsen outcome, whereas hypothermia is potentially neuroprotective. The antipyretic effects of acetaminophen were...

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Bibliographic Details
Published in:Stroke (1970) 2002-01, Vol.33 (1), p.130-135
Main Authors: Kasner, Scott E, Wein, Theodore, Piriyawat, Paisith, Villar-Cordova, Carlos E, Chalela, Julio A, Krieger, Derk W, Morgenstern, Lewis B, Kimmel, Stephen E, Grotta, James C
Format: Article
Language:English
Subjects:
Acetaminophen - therapeutic use
Acute Disease
Aged
Body Temperature - drug effects
Double-Blind Method
Female
Fever - prevention & control
Humans
Hypothermia - chemically induced
Male
Stroke - diagnosis
Stroke - prevention & control
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Summary:Mild alterations in temperature have prominent effects on ischemic cell injury and stroke outcome. Elevated core body temperature (CBT), even if mild, may exacerbate neuronal injury and worsen outcome, whereas hypothermia is potentially neuroprotective. The antipyretic effects of acetaminophen were hypothesized to reduce CBT. This was a randomized, controlled clinical trial at 2 university hospitals. Patients were included if they had stroke within 24 hours of onset of symptoms, National Institutes of Health Stroke Scale (NIHSS) score > or =5, initial CBT
ISSN:0039-2499
1524-4628
DOI:10.1161/hs0102.101477