In vivo interaction of cocaine with the dopamine transporter as measured by voltammetry

The goal of this review is to describe what the voltammetry technique tells us about cocaine–dopamine transporter (DAT) interactions and the subsequent changes in extracellular dopamine levels in the brain. The primary advantage of voltammetry, in this regard, is the capability for kinetic analysis...

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Bibliographic Details
Published in:European journal of pharmacology 2003-10, Vol.479 (1), p.117-125
Main Authors: Greco, Phillip G., Garris, Paul A.
Format: Article
Language:English
Subjects:
Animals
Binding, Competitive - drug effects
Brain - metabolism
Cocaine
Cocaine - metabolism
Cocaine - pharmacology
DAT (dopamine transporter)
Diffusion
Dopamine
Dopamine - metabolism
Dopamine Plasma Membrane Transport Proteins
Electric Stimulation - methods
Electrochemistry - methods
Humans
Membrane Glycoproteins
Membrane Transport Proteins - metabolism
Membrane Transport Proteins - physiology
Nerve Tissue Proteins - metabolism
Nerve Tissue Proteins - physiology
Release
Voltammetry
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Summary:The goal of this review is to describe what the voltammetry technique tells us about cocaine–dopamine transporter (DAT) interactions and the subsequent changes in extracellular dopamine levels in the brain. The primary advantage of voltammetry, in this regard, is the capability for kinetic analysis in situ. Analysis of electrically evoked dynamics suggests that cocaine competitively inhibits dopamine uptake in the caudate-putamen and nucleus accumbens with a similar efficacy. The preferential increase in accumbal dopamine following systemic cocaine administration was found to be related not to a unique cocaine–DAT interaction, but rather to a unique combination of dopamine release and uptake rates. Similar enhancement occurs in sub-regions of the caudate-putamen exhibiting this release and uptake combination. Other factors such as diffusion and whether dopaminergic signaling is tonic or phasic also determine the effects of cocaine on striatal dopamine levels.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2003.08.062