Chromosomal alterations during metastasis formation of head and neck squamous cell carcinoma

Comparative genomic hybridization (CGH) was used to detect chromosomal changes during metastasis formation of head and neck squamous cell carcinomas (HNSCCs). In total, 92 tumors of 54 patients were investigated. In 34 of these, the metastases were compared to the corresponding primary tumors. The g...

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Bibliographic Details
Published in:Genes chromosomes & cancer 2002-01, Vol.33 (1), p.29-35
Main Authors: Bockmühl, Ulrike, Schlüns, Karsten, Schmidt, Sven, Matthias, Sabine, Petersen, Iver
Format: Article
Language:English
Subjects:
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - secondary
chromosome 1
chromosome 10
chromosome 11
chromosome 14
chromosome 7
chromosome 8
Chromosome Aberrations
Chromosome Deletion
Gene Amplification - genetics
Genetic Heterogeneity
Head and Neck Neoplasms - diagnosis
Head and Neck Neoplasms - genetics
Humans
Lymph Nodes - pathology
Nucleic Acid Hybridization
Statistics, Nonparametric
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Summary:Comparative genomic hybridization (CGH) was used to detect chromosomal changes during metastasis formation of head and neck squamous cell carcinomas (HNSCCs). In total, 92 tumors of 54 patients were investigated. In 34 of these, the metastases were compared to the corresponding primary tumors. The group of metastatic tumors was also compared with 20 nonmetastatic tumors. Gain of 3q was the earliest genetic marker for invasion and metastasis and also correlated with poor prognosis. Additional metastasis‐associated lesions were gains on 11q13, 7q11.2, 1q21‐q22, and losses on 8p, 11p14, 11q14‐qter, 10p12, 10q, and 14q. The incidence of the chromosomal changes was used to evaluate their significance and temporal order of appearance during tumor dissemination, thus leading to an extended progression model of HNSCC. In the clonality analysis, three different methods revealed a mean concordance of 64 and 68% between pairs of primaries and metastases, respectively. Using different similarity scores, the correct metastasis was identified from the pool of all metastatic lesions in 19–26 of the 34 cases. The study supplements previous genetic results on HNSCC pathogenesis and provides criteria for multiple tumor analysis.
ISSN:1045-2257
1098-2264
DOI:10.1002/gcc.1209