Sleep pathophysiology in posttraumatic stress disorder and idiopathic nightmare sufferers

• Published in: Biological psychiatry (1969) 2003-11, Vol.54 (10), p.1092-1098
• Main Authors: Germain, Anne, Nielsen, Tore A
• Format: Article
• Language: English
• Subjects: Adult; Adult and adolescent clinical studies; Anxiety - complications; Anxiety - physiopathology; Anxiety disorders. Neuroses; Biological and medical sciences; Chin - physiopathology; Depression - complications; Depression - physiopathology; Dreams; Electroencephalography - methods; Electromyography - methods; Electrooculography - methods; Female; Humans; Idiopathic and posttraumatic nightmares; Leg - physiopathology; Male; Manifest Anxiety Scale; Medical sciences; Middle Aged; Nervous system involvement in other diseases. Miscellaneous; Neurology; periodic leg movements in sleep; Polysomnography - methods; Post-traumatic stress disorder; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; sleep disturbances; Sleep Wake Disorders - complications; Sleep Wake Disorders - physiopathology; Stress Disorders, Post-Traumatic - complications; Stress Disorders, Post-Traumatic - physiopathology
• ISSN: 0006-3223; 1873-2402
• DOI: 10.1016/S0006-3223(03)00071-4

Nightmares are common in posttraumatic stress disorder (PTSD), but they also frequently occur in idiopathic form. Findings associated with sleep disturbances in these two groups have been inconsistent, and sparse for idiopathic nightmares. The aim of the present study was to investigate whether sleep anomalies in PTSD sufferers with frequent nightmares (P-NM) differ from those observed in non-PTSD, idiopathic nightmare (I-NM) sufferers and healthy individuals. Sleep measures were obtained from nine P-NM sufferers, 11 I-NM sufferers, and 13 healthy control subjects. All participants slept in the laboratory for two consecutive nights where electroencephalogram, electro-oculogram, chin and leg electromyogram, electrocardiogram, and respiration were recorded continuously. Posttraumatic nightmare sufferers had significantly more nocturnal awakenings than did I-NM sufferers and control subjects. Elevated indices of periodic leg movements (PLMs) during rapid eye movement (REM) and non-REM sleep characterized both P-NM and I-NM sufferers. Posttraumatic nightmare sufferers exhibit more nocturnal awakenings than do I-NM sufferers and control subjects, which supports the hypothesis of hyperarousal in sleep in PTSD sufferers; however, elevated PLM indices in both P-NM and I-NM sufferers suggest that PLMs may not be a marker of hyperarousal in sleep of PTSD sufferers. Rather, PLMs may be a correlate of processes contributing to intense negative dreaming.