FDG PET imaging in hereditary thyroid cancer

Aim: To report the role of different imaging methods in staging individuals with multiple endocrine neoplasia 2A (MEN2A) or familial medullary thyroid carcinoma (FMTC). Material and methods: Fourteen newly diagnosed gene carriers underwent cervical ultrasound scanning (US), cervical and mediastinal...

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Bibliographic Details
Published in:European journal of surgical oncology 2003-12, Vol.29 (10), p.922-928
Main Authors: Boér, A., Szakáll, S., Klein, I., Kásler, M., Vincze, B., Trón, L., Gődény, M., Herzog, H., Péter, I., Ésik, O.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Carcinoma, Medullary - diagnostic imaging
Carcinoma, Medullary - genetics
Carcinoma, Medullary - surgery
Child
Endocrinopathies
familial medullary thyroid carcinoma
Female
Fluorodeoxyglucose F18
General aspects. Associated endocrine diseases. Endocrine paraneoplasic syndromes
Humans
Male
Medical sciences
Middle Aged
multiple endocrine neoplasia type 2
Multiple Endocrine Neoplasia Type 2a - diagnostic imaging
Multiple Endocrine Neoplasia Type 2a - genetics
Multiple Endocrine Neoplasia Type 2a - surgery
Neoplasm Staging
Non tumoral diseases. Target tissue resistance. Benign neoplasms
positron emission tomography
Radiopharmaceuticals
RET proto-oncogene
Thyroid Neoplasms - diagnostic imaging
Thyroid Neoplasms - genetics
Thyroid Neoplasms - surgery
Thyroid. Thyroid axis (diseases)
thyroidectomy
Tomography, Emission-Computed
ultrasonography
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Summary:Aim: To report the role of different imaging methods in staging individuals with multiple endocrine neoplasia 2A (MEN2A) or familial medullary thyroid carcinoma (FMTC). Material and methods: Fourteen newly diagnosed gene carriers underwent cervical ultrasound scanning (US), cervical and mediastinal CT, MRI and whole-body meta-[131I]iodobenzylguanidine (MIBG) scintigraphy and [18F]fluorodeoxyglucose (FDG) PET scanning. Results: US identified seven true primary cancer. CT and MRI located only tumors ≥5 mm in diameter. MIBG scintigraphy and FDG PET could not identify MTC foci within the thyroid. Whole-body FDG PET identified two true-positive and one false-positive lymph node metastases. MIBG scintigraphy did not identify lymph node metastases. Total thyroidectomy was performed in 12 cases, and subtotal thyroidectomy in two subjects. Conclusions: Whole-body FDG PET and cervical US help stage individuals carrying mutant genes verifying MEN2A or FMTC.
ISSN:0748-7983
1532-2157
DOI:10.1016/S0748-7983(03)00137-9