Helicobacter pylori Infection and Gastric Autoimmune Diseases: Is There a Link?

ABSTRACT Background.  Helicobacter pylori is thought to be involved in atrophic body gastritis. We explored the prevalence of H. pylori infection in asymptomatic subjects with gastric parietal cell antibodies, as well as in patients with pernicious anemia, to evaluate a possible role of H. pylori ga...

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Bibliographic Details
Published in:Helicobacter (Cambridge, Mass.) Mass.), 2003-12, Vol.8 (6), p.578-584
Main Authors: Presotto, Fabio, Sabini, Beatrice, Cecchetto, Attilio, Plebani, Mario, Lazzari, Franca De, Pedini, Beniamino, Betterle, Corrado
Format: Article
Language:English
Subjects:
Adult
Aged
Anemia, Pernicious - epidemiology
Anemia, Pernicious - immunology
Anemia, Pernicious - microbiology
atrophic body gastritis
Atrophy
Autoantibodies - blood
autoimmune diseases
Autoimmune Diseases - epidemiology
Autoimmune Diseases - microbiology
chronic atrophic gastritis
Female
folic acid
gastric autoimmune diseases
Gastric Mucosa - immunology
Gastric Mucosa - microbiology
Gastric Mucosa - pathology
gastric parietal cell antibodies
gastrin
Gastritis, Atrophic - epidemiology
Gastritis, Atrophic - immunology
Gastritis, Atrophic - microbiology
Helicobacter Infections - epidemiology
Helicobacter Infections - immunology
Helicobacter Infections - pathology
Helicobacter pylori
Humans
Male
Middle Aged
Parietal Cells, Gastric - immunology
Parietal Cells, Gastric - pathology
pepsinogen I
pernicious anemia
Prevalence
vitamin B12
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Summary:ABSTRACT Background.  Helicobacter pylori is thought to be involved in atrophic body gastritis. We explored the prevalence of H. pylori infection in asymptomatic subjects with gastric parietal cell antibodies, as well as in patients with pernicious anemia, to evaluate a possible role of H. pylori gastric infection in gastric autoimmunity. Patients and Methods.  We studied 79 consecutive asymptomatic subjects with parietal cell antibodies, 24 patients with pernicious anemia, and 66 parietal cell antibody‐negative controls. All patients underwent gastric biopsies for histology and detection of H. pylori. Red blood cell count and volume, serum levels of gastrin, pepsinogen I, iron, folic acid, vitamin B12, and circulating antibodies to H. pylori and to intrinsic factor were also determined. Results.  We found an atrophic body gastritis in 14 of the 79 asymptomatic subjects with parietal cell antibodies (18%) and in 2 of the 66 controls (3%) (p = .01). Mean levels of gastrin were increased (p 
ISSN:1083-4389
1523-5378
DOI:10.1111/j.1523-5378.2003.00187.x