Comparison of corneal epithelial cellular growth on synthetic cornea materials

The application of artificial corneas for severely wounded ocular surfaces has always encountered the problem of biocompatibility with corneal epithelial cells (CECs). For the eye to stay healthy, it must continually have a complete sheet of CECs across the artificial corneal surface. Various surfac...

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Bibliographic Details
Published in:Biomaterials 2002-03, Vol.23 (5), p.1369-1373
Main Authors: George, Andrew, Pitt, William G.
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
Cattle
Cell Culture Techniques - methods
Cell Division
Cell growth
Cell Movement
Copolymerization
Cornea - cytology
Corneal epithelial cell
Epithelial Cells - cytology
Keratoprosthesis
Kinetics
Mathematical model
Mitosis
Models, Theoretical
Phospholipids - chemistry
Polycarbonates
Polycarboxylate Cement - chemistry
Polyhydroxyethyl Methacrylate - chemistry
Polymer
Polymethyl methacrylates
Polystyrenes
Polystyrenes - chemistry
Polyvinyl Alcohol - chemistry
Polyvinyl alcohols
Rate constants
Rubber
Silicones
Silicones - chemistry
Surface treatment
Time Factors
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Summary:The application of artificial corneas for severely wounded ocular surfaces has always encountered the problem of biocompatibility with corneal epithelial cells (CECs). For the eye to stay healthy, it must continually have a complete sheet of CECs across the artificial corneal surface. Various surface modifications of different polymeric materials have been examined to determine which have the best cellular growth rates. A mathematical model of corneal cell growth profiles on synthetic materials was formulated based upon a linear mitotic growth rate. Experimental data reported for the CEC growth on modified poly(vinyl alcohol), silicone rubber, polystyrene, and polycarbonate was analyzed using the model to estimate the linear mitotic rate constant ( k). The model proved to be useful in comparing data from different investigators. Plasma-induced graft copolymerized poly(hydroxyethyl methacrylate) (pHEMA) on silicone rubber provided the best growth rate from this particular set of data.
ISSN:0142-9612
1878-5905
DOI:10.1016/S0142-9612(01)00257-5