Free Radicals and Disease

Free radicals and reactive oxygen species (ROS) have been associated with the etiology and/or progression of a number of diseases and in aging. Many of the proteins oxidatively modified by free radicals contain side-chain carbonyl derivatives, which can be used as markers for protein oxidation. The...

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Bibliographic Details
Published in:Archives of biochemistry and biophysics 2002-01, Vol.397 (2), p.354-359
Main Authors: Moskovitz, Jackob, Yim, Moon Bin, Chock, P.Boon
Format: Article
Language:English
Subjects:
Aging - physiology
Aldehydes - metabolism
Amyotrophic Lateral Sclerosis - etiology
Amyotrophic Lateral Sclerosis - genetics
Brain Chemistry
Dermis - chemistry
Dermis - cytology
Free Radicals - metabolism
Humans
Ketones - metabolism
Lens, Crystalline - chemistry
Lens, Crystalline - cytology
Methionine Sulfoxide Reductases
Models, Biological
Oxidoreductases - metabolism
Protein Processing, Post-Translational
Reactive Nitrogen Species - metabolism
Reactive Oxygen Species - metabolism
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Summary:Free radicals and reactive oxygen species (ROS) have been associated with the etiology and/or progression of a number of diseases and in aging. Many of the proteins oxidatively modified by free radicals contain side-chain carbonyl derivatives, which can be used as markers for protein oxidation. The protein carbonyl content has been quantitated as a function of age for human cultured dermal fibroblasts, lens, and brain tissue. These data were analyzed using a simple autocatalytic model with the assumption that free radicals randomly oxidize proteins or peptides to form carbonyl derivatives and lead to their inactivation. The carbonylated proteins and peptides are highly susceptible to proteolytic degradation. Implication of free radicals in aging and in age-dependent susceptibility to neurodegenerative diseases will be discussed in light of this simplified kinetic model.
ISSN:0003-9861
1096-0384
DOI:10.1006/abbi.2001.2692