Cytokine polymorphism frequencies in the Greek Cypriot population

Summary There is considerable evidence to suggest that several cytokine genes are polymorphic, resulting in differential transcription and protein expression levels among individuals. It has also been demonstrated that ethnicity can be a determinant for distinctive cytokine polymorphism frequencies....

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Bibliographic Details
Published in:European journal of immunogenetics 2003-10, Vol.30 (5), p.341-343
Main Authors: Costeas, P. A., Koumas, L., Koumouli, A., Kyriakou-Giantsiou, A., Papaloizou, A.
Format: Article
Language:English
Subjects:
Cyprus
Cytokines - genetics
Female
Gene Frequency
Genotype
Humans
Male
Polymorphism, Genetic
Promoter Regions, Genetic
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Summary:Summary There is considerable evidence to suggest that several cytokine genes are polymorphic, resulting in differential transcription and protein expression levels among individuals. It has also been demonstrated that ethnicity can be a determinant for distinctive cytokine polymorphism frequencies. In this study, we evaluated the distribution of cytokine gene polymorphisms in 100 healthy Greek Cypriot subjects, using polymerase chain reaction–sequence‐specific primers (PCR‐SSP) typing analysis. Cytokine gene polymorphisms were determined for transforming growth factor (TGF) β1 codon 10 (TGFβc10; C to T), TGFβ1 codon 25 (TGFβc25; G to C), tumour necrosis factor α (TNFα) promoter −308 (G to A), interleukin (IL)‐6 promoter −174 (G to C), IL‐10 promoter −1082 (G to A), IL‐10 promoter −819 (C to T), IL‐10 promoter −592 (C to A) and interferon γ (IFNγ) intron 1 +874 (A to T). Frequencies for the above cytokine genotypes were calculated for the Greek Cypriot population.
ISSN:0960-7420
1365-2370
DOI:10.1046/j.1365-2370.2003.00413.x