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Infantile Spasms in a Patient with Williams Syndrome and Craniosynostosis

A patient with Williams syndrome, craniosynostosis, and infantile spasms is described. At age 6 months, the infant demonstrated infantile spasms and craniosynostosis and was operated on for craniosynostosis and treated with adrenocorticotropic hormone (ACTH) for the infantile spasms. ACTH completely...

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Bibliographic Details
Published in:Epilepsia (Copenhagen) 2003-11, Vol.44 (11), p.1459-1462
Main Authors: Morimoto, Masafumi, An, Byongmun, Ogami, Aya, Shin, Noriko, Sugino, Yuriko, Sawai, Yasuko, Usuku, Tomohiro, Tanaka, Masayuki, Hirai, Kiyoshi, Nishimura, Akira, Hasegawa, Koh, Sugimoto, Tohru
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Language:English
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Summary:A patient with Williams syndrome, craniosynostosis, and infantile spasms is described. At age 6 months, the infant demonstrated infantile spasms and craniosynostosis and was operated on for craniosynostosis and treated with adrenocorticotropic hormone (ACTH) for the infantile spasms. ACTH completely controlled the seizures, but was halted because of the progression of ventricular hypertrophy. The seizure returned, and he was found to have elfin face, failure‐to‐thrive, developmental delay, and dental malformation in addition to congenital heart defects. High‐resolution chromosome analysis revealed interstitial deletion of 7q11.22‐q11.23. Therefore his clinical and cytogenetic diagnosis was Williams syndrome. Thyrotropin‐releasing hormone (TRH) therapy reduced his seizures and improved the findings of EEG without cardiac side effects. In addition, his psychomotor development was slightly improved.
ISSN:0013-9580
1528-1167
DOI:10.1046/j.1528-1157.2003.34703.x