Complete disproportionation of duplex poly(dT)poly(dA) into triplex poly(dT)poly(dA)poly(dT) and poly(dA) by coralyne

Coralyne is a small crescent-shaped molecule known to intercalate duplex and triplex DNA. We report that coralyne can cause the complete and irreversible disproportionation of duplex poly(dT)*poly(dA). That is, coralyne causes the strands of duplex poly(dT)*poly(dA) to repartition into equal molar e...

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Bibliographic Details
Published in:Nucleic acids research 2002-02, Vol.30 (4), p.983-992
Main Authors: Polak, Matjaz, Hud, Nicholas V
Format: Article
Language:English
Subjects:
Base Pairing
Berberine Alkaloids - chemistry
Berberine Alkaloids - pharmacology
Circular Dichroism
DNA - chemistry
DNA - drug effects
DNA - metabolism
Kinetics
Models, Chemical
Nucleic Acid Conformation
Nucleic Acid Denaturation
Poly A - chemistry
Poly A - metabolism
Poly dA-dT - chemistry
Poly dA-dT - metabolism
Polydeoxyribonucleotides - chemistry
Polydeoxyribonucleotides - metabolism
Temperature
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